Genomic organization of mouse dishevelled genes

被引：9
|
作者：
Yang, YS
Lijam, N
Sussman, DJ
Tsang, M
机构：
[1] UNIV MARYLAND,DIV HUMAN GENET,DEPT OBSTET & GYNECOL,BALTIMORE,MD 21201
[2] NIH,LGDR,NCHGR,BETHESDA,MD 20892
来源：
GENE | 1996年 / 180卷 / 1-2期
关键词：
what signal transduction; exon/intron comparison; development;
D O I：
10.1016/S0378-1119(96)00430-1
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
We report the isolation and characterization of two new genomic loci corresponding to the mouse Dishevelled (Dvl) genes Dvl2 and Dvl3. The Dvl genes are homologs of the Drosophila dsh segment polarity gene, and are involved in the Wnt/wingless signal transduction pathway. Dvl2 and Dvl3 genomic clones were isolated from a mouse 129 strain lambda FIXII genomic library and have identical exon/intron organization to Dvl1. All three Dishevelled genes span 15 exons and 14 introns and have a number of conserved splice junction sites.
引用
收藏
页码：121 / 123
页数：3
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