Reactions of alkynes with trisubstituted (Z)-bromoalkenyl-pinacolboronates towards the synthesis of 1,2,4,6-tetrasubstituted benzenes

被引：3

作者：

Yalagala, Ravi Shekar ^{[1
]}

Yan, Hongbin ^{[1
]}

机构：

[1] Brock Univ, Dept Chem, St Catharines, ON L2S 3A1, Canada

来源：

TETRAHEDRON LETTERS | 2014年 / 55卷 / 34期

关键词：

Tetrasubstituted benzene; Aromatization; Bromoalkene pinacolboronate; Terminal alkyne; Cyclization; TERMINAL ALKYNES; 1,2,4,5-TETRASUBSTITUTED BENZENES; TETRASUBSTITUTED BENZENES; BENZANNULATION; DERIVATIVES;

D O I：

10.1016/j.tetlet.2014.07.013

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Treatment of trisubstituted (Z)-bromoalkenyl-pinacolboronates with terminal alkynes in the presence of cuprous iodide, palladium(0) tetrakis(triphenylphosphine) and Hunig's base leads to the formation of 1,2,4,6-tetrasubstituted aromatic compounds in a one-pot fashion. Substrate scope was shown for three trisubstituted (Z)-bromoalkenyl-pinacolboronates and four terminal alkynes. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：4830 / 4832

页数：3

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