Reactions of alkynes with trisubstituted (Z)-bromoalkenyl-pinacolboronates towards the synthesis of 1,2,4,6-tetrasubstituted benzenes

被引：3
|
作者：
Yalagala, Ravi Shekar [1 ]
Yan, Hongbin [1 ]
机构：
[1] Brock Univ, Dept Chem, St Catharines, ON L2S 3A1, Canada
来源：
TETRAHEDRON LETTERS | 2014年 / 55卷 / 34期
关键词：
Tetrasubstituted benzene; Aromatization; Bromoalkene pinacolboronate; Terminal alkyne; Cyclization; TERMINAL ALKYNES; 1,2,4,5-TETRASUBSTITUTED BENZENES; TETRASUBSTITUTED BENZENES; BENZANNULATION; DERIVATIVES;
D O I：
10.1016/j.tetlet.2014.07.013
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Treatment of trisubstituted (Z)-bromoalkenyl-pinacolboronates with terminal alkynes in the presence of cuprous iodide, palladium(0) tetrakis(triphenylphosphine) and Hunig's base leads to the formation of 1,2,4,6-tetrasubstituted aromatic compounds in a one-pot fashion. Substrate scope was shown for three trisubstituted (Z)-bromoalkenyl-pinacolboronates and four terminal alkynes. (C) 2014 Elsevier Ltd. All rights reserved.
引用
收藏
页码：4830 / 4832
页数：3
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