Clinical Proteomics in Cancer Research

被引：1
|
作者：
Lopez, Elena [1 ]
Madero, Luis [1 ]
Melen, Gustavo J. [1 ]
Ramirez, Manuel [1 ]
Roukos, Dimitrios H. [2 ,3 ]
Cho, William C. [4 ]
机构：
[1] Hosp Infantil Univ Nino Jesus, Dept Oncohematol, Madrid 28009, Spain
[2] Univ Hosp Ioannina, Dept Surg, Ioannina, Greece
[3] Univ Ioannina, Biosyst & Synthet Genom Network Med, GR-45110 Ioannina, Greece
[4] Queen Elisabeth Hosp, Dept Clin Oncol, Hong Kong, Hong Kong, Peoples R China
来源：
CURRENT PROTEOMICS | 2013年 / 10卷 / 02期
关键词：
Cancer; clinical proteomics; personalized medicine; omics; SPECTROMETRY-BASED PROTEOMICS; RESPONSE EVALUATION CRITERIA; TANDEM MASS-SPECTROMETRY; QUANTITATIVE PROTEOMICS; BIOMARKER DISCOVERY; 2-DIMENSIONAL ELECTROPHORESIS; PHOSPHOPEPTIDE ENRICHMENT; ELECTROSPRAY-IONIZATION; PROTEIN IDENTIFICATION; PERSONALIZED MEDICINE;
D O I：
10.2174/15701646112099990001
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Clinical proteomics studies are extensively being conducted in recent years. We have outlined some views about proteomics progresses for clinical research, via the understanding the molecular mechanisms of carcinogenesis, tumor response to therapy and biomarker identification versus novel therapeutic target-discovery; as well as proteome-related methods used in cancer research. Integrative concepts of development of novel therapeutic targets and the application of proteomics in drug development are also discussed. Several aspects are touched including the development of novel therapeutic targets, proteomics as a tool to discover biomarkers, discovery and validation of prognostic and predictive biomarkers, and biobanking versus proteomics. Finally, we envision the application of clinical proteomics for future personalized cancer therapies can set up a consensus that will be reached amongst the scientific community.
引用
收藏
页码：179 / 191
页数：13
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