Clinical Proteomics in Cancer Research

被引：1
|
作者：
Lopez, Elena [1 ]
Madero, Luis [1 ]
Melen, Gustavo J. [1 ]
Ramirez, Manuel [1 ]
Roukos, Dimitrios H. [2 ,3 ]
Cho, William C. [4 ]
机构：
[1] Hosp Infantil Univ Nino Jesus, Dept Oncohematol, Madrid 28009, Spain
[2] Univ Hosp Ioannina, Dept Surg, Ioannina, Greece
[3] Univ Ioannina, Biosyst & Synthet Genom Network Med, GR-45110 Ioannina, Greece
[4] Queen Elisabeth Hosp, Dept Clin Oncol, Hong Kong, Hong Kong, Peoples R China
来源：
CURRENT PROTEOMICS | 2013年 / 10卷 / 02期
关键词：
Cancer; clinical proteomics; personalized medicine; omics; SPECTROMETRY-BASED PROTEOMICS; RESPONSE EVALUATION CRITERIA; TANDEM MASS-SPECTROMETRY; QUANTITATIVE PROTEOMICS; BIOMARKER DISCOVERY; 2-DIMENSIONAL ELECTROPHORESIS; PHOSPHOPEPTIDE ENRICHMENT; ELECTROSPRAY-IONIZATION; PROTEIN IDENTIFICATION; PERSONALIZED MEDICINE;
D O I：
10.2174/15701646112099990001
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Clinical proteomics studies are extensively being conducted in recent years. We have outlined some views about proteomics progresses for clinical research, via the understanding the molecular mechanisms of carcinogenesis, tumor response to therapy and biomarker identification versus novel therapeutic target-discovery; as well as proteome-related methods used in cancer research. Integrative concepts of development of novel therapeutic targets and the application of proteomics in drug development are also discussed. Several aspects are touched including the development of novel therapeutic targets, proteomics as a tool to discover biomarkers, discovery and validation of prognostic and predictive biomarkers, and biobanking versus proteomics. Finally, we envision the application of clinical proteomics for future personalized cancer therapies can set up a consensus that will be reached amongst the scientific community.
引用
收藏
页码：179 / 191
页数：13
相关论文
共 50 条
  • [1] Genomics and proteomics: Emerging technologies in clinical cancer research
    Chung, Christine H.
    Levy, Shawn
    Chaurand, Pierre
    Carbone, David P.
    CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY, 2007, 61 (01) : 1 - 25
  • [2] Proteomics in cancer research: Are we ready for clinical practice?
    Maes, Evelyne
    Mertens, Inge
    Valkenborg, Dirk
    Pauwels, Patrick
    Rolfo, Christian
    Baggerman, Geert
    CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY, 2015, 96 (03) : 437 - 448
  • [3] Clinical proteomics: The application of proteomics in the research of clinical medicine
    Li, F
    Fang, Y
    Xiao, ZQ
    Chen, ZC
    PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS, 2006, 33 (01) : 5 - 9
  • [4] Proteomics in translational cancer research: biomarker discovery for clinical applications
    Cho, William C. S.
    EXPERT REVIEW OF PROTEOMICS, 2014, 11 (02) : 131 - 133
  • [5] Proteomics in cancer research
    Wu, W
    Hu, W
    Kavanagh, JJ
    INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER, 2002, 12 (05) : 409 - 423
  • [6] PROTEOMICS IN CANCER RESEARCH
    Tsangaris, George Th.
    ANTICANCER RESEARCH, 2008, 28 (5C) : 3522 - 3522
  • [7] Proteomics in cancer research
    Li, F
    Guan, YJ
    Chen, ZC
    PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS, 2001, 28 (02) : 164 - 167
  • [8] Proteomics in cancer research
    Chen, ZC
    Xiao, ZQ
    PROCEEDINGS OF THE 2003 SYMPOSIUM OF CHINA POSTDOCTORS AND ACADEMICIANS ON LIFE SCIENCE, 2003, : 32 - 35
  • [9] Proteomics in clinical prostate research
    Hellstrom, Magnus
    Jonmarker, Sara
    Lehtio, Janne
    Auer, Gert
    Egevad, Lars
    PROTEOMICS CLINICAL APPLICATIONS, 2007, 1 (09) : 1058 - 1065
  • [10] Proteomics in colorectal cancer translational research: Biomarker discovery for clinical applications
    de Wit, Meike
    Fijneman, Remond J. A.
    Verheul, Henk M. W.
    Meijer, Gerrit A.
    Jimenez, Connie R.
    CLINICAL BIOCHEMISTRY, 2013, 46 (06) : 466 - 479
12345