Synthesis of Fluoromethyl-Substituted Cyclopentanones via Radical Fluorination and 1,2-Alkyl Migration Cascade of Alkenyl Cyclobutanols

被引：27

作者：

Kim, Yubin ^{[1
]}

Kim, Dae Young ^{[1
]}

机构：

[1] Soonchunhyang Univ, Dept Chem, Asan 31538, Chungnam, South Korea

来源：

ASIAN JOURNAL OF ORGANIC CHEMISTRY | 2019年 / 8卷 / 05期

基金：

新加坡国家研究基金会;

关键词：

fluorination; rearrangement; 1,2 migration; radical reactions; ring expansion; CATALYTIC ENANTIOSELECTIVE FLUORINATION; VISIBLE-LIGHT PHOTOREDOX; BETA-KETO-ESTERS; MANNICH-TYPE REACTIONS; ALPHA-CYANO ACETATES; ASYMMETRIC FLUORINATION; ELECTROPHILIC FLUORINATION; SEMIPINACOL REARRANGEMENT; CONJUGATE ADDITION; MEDIATED FLUOROALKYLATION;

D O I：

10.1002/ajoc.201900029

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A radical fluorination/1,2-alkyl migration cascade process of alkenyl cyclobutanols was developed in this study. This approach provides a mild and convenient access to the synthesis of fluoromethyl-substituted cyclopentanone derivatives from the coupling reaction of alkenyl cyclobutanols with Selectfluor as the fluorine radical source.

引用

页码：679 / 682

页数：4

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