Entropy analysis reveals a simple linear relation between laser speckle and blood flow

被引：19

作者：

Miao, Peng ^{[1
]}

Chao, Zhen ^{[1
]}

Zhang, Yiguang ^{[1
]}

Li, Nan ^{[2
]}

Thakor, Nitish V. ^{[3
,4
]}

机构：

[1] Shanghai Univ, Sch Commun & Informat Engn, Shanghai 200444, Peoples R China

[2] MIT, Dept Biol Engn, Cambridge, MA 02139 USA

[3] Natl Univ Singapore, Singapore Inst Neurotechnol SINAPSE, Singapore 117456, Singapore

[4] Johns Hopkins Univ, Dept Biomed Engn, Baltimore, MD 21205 USA

来源：

OPTICS LETTERS | 2014年 / 39卷 / 13期

基金：

中国国家自然科学基金;

关键词：

DOPPLER;

D O I：

10.1364/OL.39.003907

中图分类号：

O43 [光学];

学科分类号：

070207 ; 0803 ;

摘要：

Dynamic laser speckles contain motion information of scattering particles which can be estimated by laser speckle contrast analysis (LASCA). In this work, an entropy-based method was proposed to provide a more robust estimation of motion speed. An in vitro flow simulation experiment confirmed a simple linear relation between entropy, exposure time, and speed. A multimodality optical imaging setup is developed to validate the advantages of the entropy method based on laser speckle imaging, green light imaging, and fluorescence imaging. The entropy method overcomes traditional LASCA with less noisy interference, and extracts more visible and detailed vasculatures in vivo. Furthermore, the entropy method provides a more accurate estimation and a stable pattern of blood flow activations in the rat's somatosensory area under multitrial hand paw stimulations. (C) 2014 Optical Society of America

引用

页码：3907 / 3910

页数：4

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