Synthesis of Substituted 1,8-Naphthyridine-3-carboxylates from Baylis-Hillman Adducts of Substituted 2-Chloronicotinaldehydes

被引：29

作者：

Narender, Puli ^{[2
]}

Ravinder, Mettu ^{[2
]}

Sadhu, Partha Sarathi ^{[2
]}

Raju, Bhimapaka China ^{[1
]}

Ramesh, Chilukuri ^{[3
]}

Rao, Vaidya Jayathirtha ^{[2
,3
]}

机构：

[1] Indian Inst Chem Technol, Organ Chem Div 1, Hyderabad 500607, Andhra Pradesh, India

[2] Indian Inst Chem Technol, Organ Chem Div 2, Hyderabad 500607, Andhra Pradesh, India

[3] Natl Inst Pharmaceut Educ & Res, Hyderabad 500037, Andhra Pradesh, India

来源：

HELVETICA CHIMICA ACTA | 2009年 / 92卷 / 05期

关键词：

ANTIMICROBIAL ACTIVITY; HETEROCYCLIC-COMPOUNDS; CONVENIENT SYNTHESIS; SELECTIVE SYNTHESIS; ANTITUMOR AGENTS; DERIVATIVES; QUINOLINES; NAPHTHYRIDINES; FACILE; CHEMISTRY;

D O I：

10.1002/hlca.200800352

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A series of substituted 1,8-naphthyridine-3-carboxylates were synthesized for the first time from the Baylis-Hillman adducts obtained from 2-chloronicotinaldehyde derivatives. Three methods were adopted to synthesize 1,8-naphthyridine-3-carboxylates, of which the azide-reduction route (Scheme 5) gave the best yields compared to the other attempted methods (Schemes 2 and 3).

引用

页码：959 / 966

页数：8

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