Potential application of gelatin scaffolds prepared through in situ gas foaming in skin tissue engineering

被引：20
|
作者：
Poursamar, S. Ali [1 ]
Hatami, Javad [2 ,3 ]
Lehner, Alexander N. [4 ,5 ]
da Silva, Claudia L. [2 ,3 ]
Ferreira, Frederico Castelo [2 ,3 ]
Antunes, A. P. M. [1 ]
机构：
[1] Univ Northampton, Inst Creat Leather Technol, Northampton NN2 7AL, Northants, England
[2] Univ Lisbon, Inst Super Tecn, Dept Bioengn, P-1699 Lisbon, Portugal
[3] Univ Lisbon, Inst Super Tecn, Inst Bioengn & Biosci, P-1699 Lisbon, Portugal
[4] Univ Northampton, Ctr Phys Act & Chron Dis, Sch Hlth, Northampton NN2 7AL, England
[5] Univ Northampton, Aging Res Ctr, Sch Hlth, Inst Hlth & Wellbeing, Northampton NN2 7AL, England
来源：
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS | 2016年 / 65卷 / 06期
关键词：
Gelatin; wound dressing; gas foaming; tensile strength; cytotoxicity; CROSS-LINKING AGENTS; ARTIFICIAL SKIN; COLLAGEN; ACID; MECHANISM;
D O I：
10.1080/00914037.2015.1119688
中图分类号：
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号：
0805 ; 080501 ; 080502 ;
摘要：
Gelatin's excellent foaming ability allows the application of in situ gas foaming as a preparation technique for porous scaffold development. Here, a new iterative experimental design for in situ gas foaming method is reported. The prepared scaffolds were studied for applying the findings to the future skin tissue engineering scaffolds. The thermal stability, mechanical properties, and pore structure of the scaffolds are reported and their degradation resistance by using collagenase enzyme and their cytotoxicity by using fibroblasts were studied. The results of this study demonstrated that gas foaming method can be modified to produce an interconnected porous structure with enhanced mechanical properties. [GRAPHICS] .
引用
收藏
页码：315 / 322
页数：8
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