Tailoring the pore structure of PCL scaffolds for tissue engineering prepared via gas foaming of multi-phase blends

被引：78
|
作者：
Salerno, A. [1 ,2 ,3 ]
Di Maio, E. [4 ]
Iannace, S. [3 ]
Netti, P. A. [1 ,2 ,4 ]
机构：
[1] Interdisciplinary Res Ctr Biomat CRIB, I-80125 Naples, Italy
[2] Italian Inst Technol, I-80125 Naples, Italy
[3] Natl Res Council IMCB CNR, Inst Composite & Biomed Mat, I-80125 Naples, Italy
[4] Univ Naples Federico II, Dept Mat & Prod Engn, I-80125 Naples, Italy
来源：
JOURNAL OF POROUS MATERIALS | 2012年 / 19卷 / 02期
关键词：
Gas foaming; PCL; Pore structure; Scaffold; Tissue engineering; POLYMER SCAFFOLDS; POROUS SCAFFOLD; SIZE; DESIGN; COLONIZATION; DEGRADATION; FABRICATION; POROSITY; GROWTH;
D O I：
10.1007/s10934-011-9458-9
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
The aim of this study was the design of poly(epsilon-caprolactone) (PCL) scaffolds characterized by well controlled pore structures obtained by gas foaming of multi-phase blends of PCL and thermoplastic gelatin (TG). Co-continuous blends made of PCL and TG were prepared by melt mixing and, subsequently gas foamed in an autoclave to induce the formation of the porous network. A mixture of N-2 and CO2 was used as blowing agent and the foaming process performed at temperature higher than PCL melting, in the range 70-110 degrees C. The foams were finally soaked in water at 37 degrees C to selectively extract the TG and achieve the final pore structure. The results of this study demonstrated that the proposed approach allowed to tailor the micro-structural properties of PCL scaffolds for tissue engineering.
引用
收藏
页码：181 / 188
页数：8
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