Metallo-Supramolecular Nanogels for Intracellular pH-Responsive Drug Release

被引：11
|
作者：
Yao, Xuemei [1 ]
Chen, Li [1 ]
Chen, Xiaofei [1 ]
He, Chaoliang [2 ]
Zhang, Jingping [1 ]
Chen, Xuesi [2 ]
机构：
[1] NE Normal Univ, Dept Chem, Changchun 130024, Peoples R China
[2] Chinese Acad Sci, Changchun Inst Appl Chem, Key Lab Polymer Ecomat, Changchun 130022, Peoples R China
来源：
MACROMOLECULAR RAPID COMMUNICATIONS | 2014年 / 35卷 / 19期
基金：
中国国家自然科学基金;
关键词：
biocompatibility; drug delivery; metallo-supromolecular nanogels; pH responsiveness; DELIVERY PLATFORMS; MICELLES; NANOPARTICLES; COPOLYMER; POLYMERS; CHEMISTRY; VESICLES; SYSTEMS; CELLS; WATER;
D O I：
10.1002/marc.201400291
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
A simple process is developed to fabricate metallo-supramolecular nanogels (MSNs) by the metallo-supramolecular-coordinated interaction between histidine and iron-meso-tetraphenylporphin. MSNs are composed of histidine-modified dextran (DH) and iron-meso-tetraphenylporphin (Fe-Por) and exhibit excellent biocompatibility and stability. MSNs show pH responsiveness in the intracellular mildly acidic environment, which has great potential for acid-triggered drug release delivery. In vitro drug release profiles demonstrate that the pH-dependent disassembly of MSNs to histidine and Por results in a quicker release rate of loaded-DOX at pH 5.3, while at pH 7.4 MSNs could hinder the release of loaded-DOX due to the enhanced stability of MSNs.
引用
收藏
页码：1697 / 1705
页数：9
相关论文
共 50 条
  • [41] Natural melanin: A potential pH-responsive drug release device
    Araujo, Marco
    Viveiros, Raquel
    Correia, Tiago R.
    Correia, Ilidio J.
    Bonifacio, Vasco D. B.
    Casimiro, Teresa
    Aguiar-Ricardo, Ana
    INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2014, 469 (01) : 140 - 145
  • [42] Carboxymethyl cellulose hydrogel for pH-responsive drug release of curcumin
    Nishadani, D. K. S.
    Gunathilake, Thennakoon M. Sampath Udeni
    Ching, Yern Chee
    Noothalapati, Hemanth
    IRANIAN POLYMER JOURNAL, 2024, 33 (10) : 1449 - 1467
  • [43] Rheological properties and drug release characteristics of pH-responsive hydrogels
    Aminabhavi, TM
    Agnihotri, SA
    Naidu, BVK
    JOURNAL OF APPLIED POLYMER SCIENCE, 2004, 94 (05) : 2057 - 2064
  • [44] Drug release from pH-responsive thermogelling pentablock copolymers
    Determan, Michael D.
    Cox, James P.
    Mallapragada, Surya K.
    JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, 2007, 81A (02) : 326 - 333
  • [45] pH-responsive electrospun nanofibrous membrane for drug controlled release
    Li, Wei
    Shi, Yang
    Luo, Tian
    Liu, Siyu
    Liu, Li
    JOURNAL OF CONTROLLED RELEASE, 2013, 172 (01) : E71 - E71
  • [46] Hydrogels: from controlled release to pH-responsive drug delivery
    Gupta, P
    Vermani, K
    Garg, S
    DRUG DISCOVERY TODAY, 2002, 7 (10) : 569 - 579
  • [47] Aggregates of silicon quantum dots as a drug carrier: selective intracellular drug release based on pH-responsive aggregation/dispersion
    Ohta, Seiichi
    Yamura, Kentaro
    Inasawa, Susumu
    Yamaguchi, Yukio
    CHEMICAL COMMUNICATIONS, 2015, 51 (29) : 6422 - 6425
  • [48] Hollow mesoporous hydroxyapatite nanoparticles (hmHANPs) with enhanced drug loading and pH-responsive release properties for intracellular drug delivery
    Yang, Ya-Huei
    Liu, Chia-Hung
    Liang, Yung-He
    Lin, Feng-Huei
    Wu, Kevin C. -W.
    JOURNAL OF MATERIALS CHEMISTRY B, 2013, 1 (19) : 2447 - 2450
  • [49] 5-Fluorouracil uptake and release from pH-responsive nanogels: An experimental and computational study
    Naranjo, Adrian Ges
    Cobas, Herlys Viltres
    Gupta, Nishesh Kumar
    Lopez, Katy Rodriguez
    Pena, Aldo Martinez
    Sacasas, Daniel
    Brito, Ruben Alvarez
    JOURNAL OF MOLECULAR LIQUIDS, 2022, 362
  • [50] Drug-initiated, pH-responsive polycarbonate nanoparticles for controlled drug release
    Baumgartner, Ryan B.
    Yin, Qian
    Cheng, Jianjun
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2013, 246
12345