3-amino-2(1H)-quinolones by cyclization of N-acylated anthranilic acid derivatives

被引：12
|
作者：
Rehwald, M
Gewald, K
Lankau, HJ
Unverferth, K
机构：
[1] Institute of Organic Chemistry, Technical University of Dresden
来源：
HETEROCYCLES | 1997年 / 45卷 / 03期
关键词：
D O I：
10.3987/COM-96-7700
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Reaction of secondary amines with the N-(iodoacetyl)anthranilic acid derivatives, 2-(iodoacetylamino)acetophenone and 2-(iodoacetylamino)benzophenone yields 3-amino-2(1H)-quinolones in two steps. Analogously heterocondensed 5-amino-6(7H)-pyrazolo[5,4-b]pyridones were prepared. Hydroxyquinolines were subjected to Cl/OH exchange to give chloroquinolines, which are convenient for consecutive reactions.
引用
收藏
页码：483 / 492
页数：10
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