Treatment Outcome of the Combination Therapy of High-dose rate Intracavitary Brachytherapy and Intensity-modulated Radiation Therapy With Central-shielding for Cervical Cancer

被引：3
|
作者：
Mukai, Yuki [1 ,2 ]
Minagawa, Yumiko [2 ]
Inoue, Hiromi [3 ]
Sato, Akiko [1 ]
Matsui, Kengo [2 ]
Fukuda, Takanori [3 ]
Onuma, Kazuya [3 ]
Hongo, Hideyuki [2 ]
Shirata, Ryosuke [2 ]
Nagata, Hironori [2 ]
Hashimoto, Harumitu [4 ]
Inoue, Tomio [5 ]
Hata, Masaharu [1 ]
Omura, Motoko [2 ]
机构：
[1] Yokohama City Univ, Dept Radiat Oncol, Grad Sch Med, Yokohama, Kanagawa, Japan
[2] Shonan Kamakura Gen Hosp, Dept Radiat Oncol, Kamakura, Kanagawa, Japan
[3] Shonan Kamakura Gen Hosp, Dept Obstet & Gynecol, Kamakura, Kanagawa, Japan
[4] Shonan Fujisawa Tokushukai Hosp, Dept Radiat Oncol, Fujisawa, Kanagawa, Japan
[5] Shonan Kamakura Gen Hosp, Dept Adv Med Ctr, Kamakura, Kanagawa, Japan
来源：
IN VIVO | 2020年 / 34卷 / 06期
关键词：
Uterus cervical cancer; high-dose rate intracavitary brachytherapy; intensity-modulated radiation therapy; whole pelvic radiation therapy; central shielding; EXTERNAL-BEAM RADIOTHERAPY; SQUAMOUS-CELL CARCINOMA; CLINICAL TARGET VOLUME; HEMATOLOGIC TOXICITY; HELICAL TOMOTHERAPY; UTERINE CERVIX; LYMPH-NODES; CHEMORADIATION; CHEMOTHERAPY; PROLONGATION;
D O I：
10.21873/invivo.12177
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Background/Aim: This study aimed to evaluate the clinical outcome of intensity-modulated radiation therapy (IMRT) and high-dose-rate intracavitary brachytherapy (HDR-ICBT) in uterine cervical cancer (UCC). IMRT consisted of whole-pelvic radiation therapy (WPRT) and sequential WPRT with central-shielding (WPRT-CS). Patients and Methods: Thirty UCC patients treated with IMRT using TomoTherapy, were retrospectively analyzed. Results: The median dose of WPRT and WPRT-CS was 36 and 14.4 Gy and the median total dose of these was 50 Gy in 25 fractions (Fr). Median HDR-ICBT dose/Fr to Point A was 25 Gy/5 Fr. Median 2 Gy per fraction-equivalent dose (EQD2) of combined WPRT and HDR-ICBT to Point A (alpha/beta=10) was 71.0 Gy. The 3-year local control, disease-free survival, and overall survival rates were 89.9%, 83.3%, and 86.3%. Conclusion: IMRT of WPRT and WPRT-CS given in combination with HDR-ICBT was a feasible therapy resulting in good disease control and tolerance in patients with UCC.
引用
收藏
页码：3387 / 3398
页数：12
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