Coordinate recruitment of E-cadherin and ALCAM to cell-cell contacts by α-catenin

被引：46

作者：

Tomita, K ^{[1
]}

van Bokhoven, A ^{[1
]}

Jansen, CFJ ^{[1
]}

Bussemakers, MJG ^{[1
]}

Schalken, JA ^{[1
]}

机构：

[1] Univ Nijmegen Hosp, Urol Res Lab, NL-6500 HB Nijmegen, Netherlands

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2000年 / 267卷 / 03期

关键词：

ALCAM; E-cadherin; alpha-catenin; prostate cancer;

D O I：

10.1006/bbrc.1999.2040

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Here we report on the role of alpha-catenin in the cellular localization of activated leukocyte cell adhesion molecule, ALCAM and cadherin-mediated cell adhesion in human prostate cancer cells. Cell lines that have a functional E-cadherin-mediated cell adhesion (DU-145 and LNCaP) show ALCAM staining at cell-cell contacts. In contrast, in cell lines that lack alpha-catenin expression (ALVA-31, PC-3, and PPC-1), E-cadherin-mediated adhesion is disturbed and ALCAM staining is cytoplasmic. A role of alpha-catenin in the recruitment of E-cadherin and ALCAM to cell-cell contacts was established by transfection of an alpha-N-catenin construct into cell lines ALVA-31 and PC-3. This resulted not only in the correct assembly of E-cadherin/alpha-catenin complexes at the cell membrane but also in localization of ALCAM to cell-cell contacts, indicating that indeed alpha-catenin affects ALCAM localization. (C) 2000 Academic Press.

引用

页码：870 / 874

页数：5

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