A Rare Case of Lupus Nephritis Presenting as Thrombotic Microangiopathy with Diffuse Pseudotubulization Possibly Caused by Atypical Hemolytic Uremic Syndrome

被引：9

作者：

Ono, Masafumi ^{[1
]}

Ohashi, Naro ^{[2
]}

Namikawa, Akio ^{[2
]}

Katahashi, Naoko ^{[2
]}

Ishigaki, Sayaka ^{[2
]}

Tsuji, Naoko ^{[2
]}

Isobe, Shinsuke ^{[2
]}

Iwakura, Takamasa ^{[2
]}

Sakao, Yukitoshi ^{[3
]}

Tsuji, Takayuki ^{[2
]}

Kato, Akihiko ^{[1
]}

Fujigaki, Yoshihide ^{[4
]}

Shimizu, Akira ^{[5
]}

Yasuda, Hideo ^{[2
]}

机构：

[1] Hamamatsu Univ Sch Med, Blood Purificat Unit, Hamamatsu, Shizuoka, Japan

[2] Hamamatsu Univ Sch Med, Dept Med 1, Div Nephrol, Hamamatsu, Shizuoka, Japan

[3] Hamana Clin, Hamamatsu, Shizuoka, Japan

[4] Teikyo Univ, Sch Med, Dept Internal Med, Tokyo, Japan

[5] Nihon Univ, Sch Med, Dept Pathol, Tokyo, Japan

来源：

INTERNAL MEDICINE | 2018年 / 57卷 / 11期

关键词：

thrombotic microangiopathy; systemic lupus erythematosus; atypical hemolytic uremic syndrome; eculizumab; pseudotubulization; COMPLEMENT INHIBITOR ECULIZUMAB; CRESCENTIC GLOMERULONEPHRITIS; EFFICACY;

D O I：

10.2169/internalmedicine.0228-17

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A 31-year-old woman was admitted to our hospital for thrombotic microangiopathy (TMA). She was diagnosed with systemic lupus erythematosus (SLE) and class V lupus nephritis. She had no aggravated SLE activity, Shiga toxin positivity, ADAMTS13 abnormality, or other causes of secondary TMA. Plasma exchange partially improved TMA, and eculizumab was introduced for suspected atypical hemolytic uremic syndrome (aHUS), as eculizumab was effective in suppressing the TMA activity. A kidney biopsy revealed diffusely organized crescents (pseudotubulization) with glomerular and arteriolar endothelial injury and subepithelial immune deposits. Thus, this was a rare case of lupus nephritis presenting as TMA with pseudotubulization possibly caused by aHUS.

引用

页码：1617 / 1623

页数：7

共 50 条

[41] Eculizumab (ECU) in Atypical Hemolytic Uremic Syndrome (aHUS) Patients with Progressing Thrombotic Microangiopathy (TMA): 2-Year Data
Greenbaum, Larry
Legendre, Christophe M.
Babu, Sunil
Furman, Richard R.
Sheerin, Neil
Cohen, David
Eitner, Frank
Delmas, Yahsou
Bedrosian, Camille L.
Loirat, Chantal
BLOOD, 2012, 120 (21)
[42] Complete Recovery from AKI: A Rare Case of Postpartum Atypical Hemolytic Uremic Syndrome
Hong, Ling
Zheng Zhihua
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2024, 35 (10):
[43] A RARE CASE OF ATYPICAL HEMOLYTIC UREMIC SYNDROME AND PRIMARY MEMBRANOUS NEPHROPATHY WITH NOVEL FINDINGS
AL-Faris, Faris
Al-Hasan, Mohammad
Mehta, Swati
Beers, Kelly
Salman, Loay
Prado, Mauricio Monrroy
AMERICAN JOURNAL OF KIDNEY DISEASES, 2021, 77 (04) : 570 - 570
[44] A Rare Case of Atypical Hemolytic Uremic Syndrome (HUS) in an Adult Male: A Catastrophic Presentation
Pokhriyal, Sindhu C.
Sule-Saa, Samuel
Alemonai, Jemima A.
Al-Ghuraibawi, Muthanna Mohammed Hasan
Pierre, Luckencia
Parkash, Sunil
Panigrahi, Kalpana
CUREUS JOURNAL OF MEDICAL SCIENCE, 2024, 16 (06)
[45] A case of atypical hemolytic uremic syndrome presenting intermittent thrombocytopenia and hemolysis with fatal acute coronary syndrome
Kim, Hyun-Je
Hong, Young-Hoon
KOREAN JOURNAL OF INTERNAL MEDICINE, 2022, 37 (04): : 879 - 880
[46] An Unusual Case of Diffuse Alveolar Hemorrhage as a Clinical Manifestation of Atypical Hemolytic Uremic Syndrome: A Case Report
Al-Shyoukh, Ahmad
Younis, Moustafa
Abughanimeh, Omar
Tahboub, Mohammad
Hamarshi, Majdi S.
CUREUS JOURNAL OF MEDICAL SCIENCE, 2019, 11 (07)
[47] A rare case of Alport syndrome, atypical hemolytic uremic syndrome and Pauci-immune crescentic glomerulonephritis
Tao, Jianling
Lieberman, Jonathan
Lafayette, Richard A.
Kambham, Neeraja
BMC NEPHROLOGY, 2018, 19
[48] A rare case of Alport syndrome, atypical hemolytic uremic syndrome and Pauci-immune crescentic glomerulonephritis
Jianling Tao
Jonathan Lieberman
Richard A. Lafayette
Neeraja Kambham
BMC Nephrology, 19
[49] Eculizumab (ECU) Inhibits Thrombotic Microangiopathy (TMA) and Improves Renal Function In Adult Patients (Pts) With Atypical Hemolytic Uremic Syndrome (aHUS)
Fakhouri, Fadi
Hourmant, Maryvonne
Cataland, Spero R.
Espinosa, Mario
Gaber, A. Osama
Menne, Jan
Minetti, Enrico
Provot, Francois
Rondeau, Eric
Ruggenenti, Piero
Weekers, Laurent
Ogawa, Masayo
Bedrosian, Camille L.
Legendre, Christophe
BLOOD, 2013, 122 (21)
[50] Eculizumab Inhibits Thrombotic Microangiopathy and Improves Renal Function in Pediatric Patients with Atypical Hemolytic Uremic Syndrome: 1-Year Update
Greenbaum, Laurence A.
Fila, Marc
Ardissino, Gianluigi
Al-Akash, Samhar I.
Evans, Jonathan H.
Lieberman, Kenneth
Maringhini, Silvio
Pape, Lars
Rees, Lesley
van de Kar, Nicole C. A. J.
Vande Walle, Johan
Ogawa, Masayo
Bedrosian, Camille L.
Licht, Christoph
BLOOD, 2014, 124 (21)

← 1 2 3 4 5 →