Haemoglobin: NO transporter, NO inactivator or NOne of the above?

被引：61
|
作者：
Hobbs, AJ
Gladwin, MT
Patel, RP
Williams, DLH
Butler, AR
机构：
[1] UCL, Wolfson Inst Biomed Res, London WC1E 6AE, England
[2] NIH, Dept Crit Care Med, Bethesda, MD 20892 USA
[3] Univ Alabama Birmingham, Dept Pathol, Ctr Free Rad Biol, Birmingham, AL 35294 USA
[4] Univ Durham, Dept Chem, Durham DH1 3LE, England
[5] Univ St Andrews, Sch Chem, St Andrews KY16 9ST, Fife, Scotland
[6] Univ St Andrews, Ctr Biomol Sci, St Andrews KY16 9ST, Fife, Scotland
来源：
TRENDS IN PHARMACOLOGICAL SCIENCES | 2002年 / 23卷 / 09期
关键词：
D O I：
10.1016/S0165-6147(02)02067-9
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The structural and functional characterization of haemoglobin (Hb) exceeds that of any other mammalian protein. Recently, the biological role attributed to Hb has been extended from the classical role in the transport and exchange of the respiratory gases O-2 and CO2 to include a third gaseous molecule, nitric oxide (NO). It is postulated that Hb might be involved in the systemic transport and delivery of NO to tissues and in the facilitation of O-2 release. However, definitive evidence for these putative activities is yet to be produced and many questions remain. Here we describe the present status of these hypotheses and their strengths and weaknesses.
引用
收藏
页码：406 / 411
页数：6
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