Hyperspectral infrared microscopy with visible light

被引:70
|
作者
Paterova, Anna, V [1 ]
Maniam, Sivakumar M. [2 ,3 ]
Yang, Hongzhi [1 ]
Grenci, Gianluca [2 ,4 ]
Krivitsky, Leonid A. [1 ]
机构
[1] ASTAR, Inst Mat Res & Engn IMRE, Singapore 138634, Singapore
[2] Natl Univ Singapore, Mechanobiol Inst, Singapore 117411, Singapore
[3] Nanyang Technol Univ, Natl Inst Educ, Singapore 637616, Singapore
[4] Natl Univ Singapore, Dept Biomed Engn, Singapore 117583, Singapore
关键词
OPTICAL PARAMETRIC OSCILLATOR; INDUCED COHERENCE; REFRACTIVE-INDEX; DOWN-CONVERSION; SPECTROSCOPY; MICROSPECTROSCOPY; INTERFERENCE; WAVELENGTH; SU-8;
D O I
10.1126/sciadv.abd0460
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Hyperspectral microscopy is an imaging technique that provides spectroscopic information with high spatial resolution. When applied in the relevant wavelength region, such as in the infrared (IR), it can reveal a rich spectral fingerprint across different regions of a sample. Challenges associated with low efficiency and high cost of IR light sources and detector arrays have limited its broad adoption. Here, we introduce a new approach to IR hyperspectral microscopy, where the IR spectral map is obtained with off-the-shelf components built for visible light. The method is based on the nonlinear interference of correlated photons generated via parametric down-conversion. In this proof-of-concept we demonstrate the chemical mapping of a patterned sample, where different areas have distinctive IR spectroscopic fingerprints. The method provides a wide field of view, fast readout, and negligible heat delivered to the sample, which opens prospects for its further development for applications in material and biological studies.
引用
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页数:7
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