Hyperspectral infrared microscopy with visible light

被引:70
|
作者
Paterova, Anna, V [1 ]
Maniam, Sivakumar M. [2 ,3 ]
Yang, Hongzhi [1 ]
Grenci, Gianluca [2 ,4 ]
Krivitsky, Leonid A. [1 ]
机构
[1] ASTAR, Inst Mat Res & Engn IMRE, Singapore 138634, Singapore
[2] Natl Univ Singapore, Mechanobiol Inst, Singapore 117411, Singapore
[3] Nanyang Technol Univ, Natl Inst Educ, Singapore 637616, Singapore
[4] Natl Univ Singapore, Dept Biomed Engn, Singapore 117583, Singapore
关键词
OPTICAL PARAMETRIC OSCILLATOR; INDUCED COHERENCE; REFRACTIVE-INDEX; DOWN-CONVERSION; SPECTROSCOPY; MICROSPECTROSCOPY; INTERFERENCE; WAVELENGTH; SU-8;
D O I
10.1126/sciadv.abd0460
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Hyperspectral microscopy is an imaging technique that provides spectroscopic information with high spatial resolution. When applied in the relevant wavelength region, such as in the infrared (IR), it can reveal a rich spectral fingerprint across different regions of a sample. Challenges associated with low efficiency and high cost of IR light sources and detector arrays have limited its broad adoption. Here, we introduce a new approach to IR hyperspectral microscopy, where the IR spectral map is obtained with off-the-shelf components built for visible light. The method is based on the nonlinear interference of correlated photons generated via parametric down-conversion. In this proof-of-concept we demonstrate the chemical mapping of a patterned sample, where different areas have distinctive IR spectroscopic fingerprints. The method provides a wide field of view, fast readout, and negligible heat delivered to the sample, which opens prospects for its further development for applications in material and biological studies.
引用
收藏
页数:7
相关论文
共 50 条
  • [1] Design of a visible-near-infrared hyperspectral microscopy optical systems
    Zhang, ZhouFeng
    Hu, BingLiang
    Yin, QinYe
    Zhang, ZhaoHui
    Yu, Tao
    FIFTH SYMPOSIUM ON NOVEL OPTOELECTRONIC DETECTION TECHNOLOGY AND APPLICATION, 2019, 11023
  • [2] Hyperspectral light sheet microscopy
    Jahr, Wiebke
    Schmid, Benjamin
    Schmied, Christopher
    Fahrbach, Florian O.
    Huisken, Jan
    NATURE COMMUNICATIONS, 2015, 6
  • [3] Hyperspectral light sheet microscopy
    Wiebke Jahr
    Benjamin Schmid
    Christopher Schmied
    Florian O. Fahrbach
    Jan Huisken
    Nature Communications, 6
  • [4] ULTRAVIOLET, VISIBLE, AND INFRARED MICROSCOPY
    HEINECKE, KJ
    ANALYTICAL CHEMISTRY, 1948, 20 (07) : 686 - 686
  • [5] MICROSCOPY IN THE ULTRAVIOLET VISIBLE AND INFRARED
    LAVIN, GI
    BIOLOGICAL BULLETIN, 1950, 99 (02): : 342 - 342
  • [6] Photon-sparse microscopy: visible light imaging using infrared illumination
    Aspden, Reuben S.
    Gemmell, Nathan R.
    Morris, Peter A.
    Tasca, Daniel S.
    Mertens, Lena
    Tanner, Michael G.
    Kirkwood, Robert A.
    Ruggeri, Alessandro
    Tosi, Alberto
    Boyd, Robert W.
    Buller, Gerald S.
    Hadfield, Robert H.
    Padgett, Miles J.
    OPTICA, 2015, 2 (12): : 1049 - 1052
  • [7] A compact visible/near infrared hyperspectral imager
    Murguia, JE
    Reeves, TD
    Mooney, JM
    Ewing, WS
    Shepherd, FD
    Brodzik, A
    INFRARED DETECTORS AND FOCAL PLANE ARRAYS VI, 2000, 4028 : 457 - 468
  • [8] Hyperspectral Microscopy with Broadband Infrared Frequency Combs
    Timmers, Henry
    Kowligy, Abijith
    Lind, Alexander J.
    Nader, Nima
    Shaw, Jonah
    Zalvidea, Dobryna
    Biegert, Jens
    Diddams, Scott A.
    2019 CONFERENCE ON LASERS AND ELECTRO-OPTICS (CLEO), 2019,
  • [9] Infrared spectroscopy with visible light
    Kalashnikov, Dmitry A.
    Paterova, Anna V.
    Kulik, Sergei P.
    Krivitsky, Leonid A.
    NATURE PHOTONICS, 2016, 10 (02) : 98 - +
  • [10] Infrared spectroscopy with visible light
    Kalashnikov D.A.
    Paterova A.V.
    Kulik S.P.
    Krivitsky L.A.
    Nature Photonics, 2016, 10 (2) : 98 - 101