Downregulation of IGF-1 decreased proliferation, migration and increased apoptosis in diabetes-impaired corneal epithelial wound healing

被引:0
|
作者
Wu, Xinyi [1 ]
机构
[1] Shandong Univ, Ophthal QiLu Hosp Ophthal, Jinan, Shandong, Peoples R China
关键词
482; cornea:; epithelium;
D O I
暂无
中图分类号
R77 [眼科学];
学科分类号
100212 ;
摘要
4680
引用
收藏
页数:1
相关论文
共 45 条
  • [21] Ganglioside GM3 Depletion Reverses Impaired Wound Healing in Diabetic Mice by Activating IGF-1 and Insulin Receptors
    Wang, Xiao-Qi
    Lee, Sarah
    Wilson, Heather
    Seeger, Mark
    Iordanov, Hristo
    Gatla, Nandita
    Whittington, Adam
    Bach, Daniel
    Lu, Jian-yun
    Paller, Amy S.
    JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2014, 134 (05) : 1446 - 1455
  • [22] NOX1 modulates proliferation, while eNOS regulates migration in the wound healing of corneal endothelial cells in culture
    Justet, Cristian
    Rinaldi, Micaela
    Schaffner, Mateo
    FREE RADICAL BIOLOGY AND MEDICINE, 2023, 208 : S20 - S21
  • [23] Increased serum sclerostin and decreased serum IGF-1 are associated with vertebral fractures among postmenopausal women with type-2 diabetes
    Ardawi, Mohammed-Salleh M.
    Akhbar, Daad H.
    AlShaikh, Abdulrahman
    Ahmed, Maimoona M.
    Qari, Mohammed H.
    Rouzi, Abdulrahim A.
    Ali, Ahmed Y.
    Abdulrafee, Adel A.
    Saeda, Mamdouh Y.
    BONE, 2013, 56 (02) : 355 - 362
  • [24] Reactive oxygen species (ROS) are essential mediators in epidermal growth factor (EGF)-stimulated corneal epithelial cell proliferation, adhesion, migration, and wound healing
    Huo, Yanan
    Qiu, Wen-Ya
    Pan, Qing
    Yao, Yu-Feng
    Xing, Kuiyi
    Lou, Marjorie F.
    EXPERIMENTAL EYE RESEARCH, 2009, 89 (06) : 876 - 886
  • [25] ROS constitute a convergence nexus in the development of IGF1 resistance and impaired wound healing in a rat model of type 2 diabetes
    Bitar, Milad S.
    Al-Mulla, Fahd
    DISEASE MODELS & MECHANISMS, 2012, 5 (03) : 375 - 388
  • [26] Epithelial injury induces keratocyte apoptosis: Hypothesized role for the interleukin-1 system in the modulation of corneal tissue organization and wound healing
    Wilson, SE
    He, YG
    Weng, J
    Li, Q
    McDowall, AW
    Vital, M
    Chwang, EL
    EXPERIMENTAL EYE RESEARCH, 1996, 62 (04) : 325 - 337
  • [27] Participation of p38 MAPK, but not p44/42 MAPK, in combined effects of substance P and IGF-1 on corneal epithelial migration
    Nakamura, M
    Chikama, TI
    Nishida, T
    BRAIN RESEARCH, 1999, 848 (1-2) : A27 - A27
  • [28] D Cultured media from adipose derived stem cells promote corneal epithelial wound healing via increased cell proliferation and DNA metabolic process
    Okamoto, Mako
    Okumura, Yuichi
    Inomata, Takenori
    Miura, Maria
    Fujimoto, Keiichi
    Hirosawa, Kunihiko
    Nagino, Ken
    Moroka, Yuki
    Hara, Fumihiro
    Nakao, Shintaro
    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2024, 65 (07)
  • [29] IGF-1 upregulates Cox2 and stimulates proliferation and migration of gastric epithelial cells in Pi3-kinase dependent manner. In vivo relevance and implications for gastric ulcer healing
    Nguyen, T
    Chai, JY
    Akahoshi, T
    Tanigawa, T
    Tarnawski, A
    GASTROENTEROLOGY, 2005, 128 (04) : A228 - A229
  • [30] Milk Fat Globule-Epidermal Growth Factor 8 Is Decreased in Intestinal Epithelium of Ulcerative Colitis Patients and Thereby Causes Increased Apoptosis and Impaired Wound Healing
    Qiu-jie Zhao
    Yan-bo Yu
    Xiu-li Zuo
    Yan-yan Dong
    Yan-qing Li
    Molecular Medicine, 2012, 18 : 497 - 506