Parathyroid autotransplantation in rats having hypoparathyroidism

被引:1
|
作者
Erikoglu, Mehmet [1 ]
Colak, Bayram [4 ]
Toy, Hatice [2 ]
Gurbilek, Mehmet [3 ]
机构
[1] Neomettin Erbakan Univ, Dept Surg, Konya, Turkey
[2] Neomettin Erbakan Univ, Dept Pathol, Konya, Turkey
[3] Neomettin Erbakan Univ, Fac Med, Biochem, Konya, Turkey
[4] Selcuk Univ, Fac Med, Dept Surg, TR-42075 Konya, Turkey
来源
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE | 2015年 / 8卷 / 09期
关键词
Parathyroid; autotransplantation; hypocalcemia; TOTAL THYROIDECTOMY; GLANDS;
D O I
暂无
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Re-implantation techniques of extracted parathyroid tissue were developed in order to prevent temporary hypocalcemia. During thyroid surgery; inadvertently removed or devascularized parathyroid gland is usually implanted in the sternocleidomastoid muscle. In this experimental study using rats with hypoparathyroidism, our aim was to investigate whether the excised parathyroid tissue could be seeded in the liver and in the peritoneum, instead of the SCM muscle. In our study, four different groups, each consisting of 10 Wistar albino rats were used (Control group, sternocleidomastoid muscle group, liver group, peritoneum group). Parathyroidectomy was performed and the parathyroid tissue was seeded into the sternocloid mastoid muscle, liver and peritoneum. After 14 days, the rats were sacrificed and levels of calcium, magnesium, phosphorus, alkaline phosphatase and parathyroid hormone were measured in rats' blood samples. The autotransplanted parathyroid tissue was then excised and examined. In all groups, parathyroid tissues were analyzed histopathologically according to calcification, necrosis, tissue loss, foreign body reaction, inflammation and fibrosis. Regarding Ca, Mg, PO4, ALP; There were no difference between the groups. When we compared control group with the other groups; a difference was observed in the levels of PTH (P<0.05). In pathological examination; regarding tissue loss; there was a difference between liver and peritoneum groups (P<0.05). In our study, we expected better result in plantings inside liver and peritone compared to SKM. However, there were no difference between the groups.
引用
收藏
页码:16328 / 16333
页数:6
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