Inclusion Body Myositis

被引：73

作者：

Dimachkie, Mazen M. ^{[1
]}

Barohn, Richard J. ^{[2
]}

机构：

[1] Univ Kansas, Med Ctr, Dept Neurol, Neurophysiol Div,Neuromuscular Sect, Kansas City, KS 66160 USA

[2] Univ Kansas, Med Ctr, Dept Neurol, Kansas City, KS 66160 USA

来源：

NEUROLOGIC CLINICS | 2014年 / 32卷 / 03期

关键词：

Inclusion body myositis; Idiopathic inflammatory myopathies; Polymyositis; Diagnosis; Pathology; Pathophysiology; Treatment; Prognosis; CYTOSOLIC 5'-NUCLEOTIDASE 1A; QUANTITATIVE ASSESSMENT; PILOT TRIAL; CLINICAL-COURSE; MUSCLE; BETA; EPIDEMIOLOGY; EXPLANATION; PREVALENCE; DISEASE;

D O I：

10.1016/j.ncl.2014.04.001

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The idiopathic inflammatory myopathies (IIMs) are a heterogenous group of rare disorders that share many similarities. In addition to sporadic inclusion body myositis (IBM), these include dermatomyositis, polymyositis, and autoimmune necrotizing myopathy. IBM is the most common IIM after age 50 years. Muscle histopathology shows endomysial inflammatory exudates surrounding and invading nonnecrotic muscle fibers often accompanied by rimmed vacuoles and protein deposits. It is likely that IBM has a prominent degenerative component. This article reviews the evolution of knowledge in IBM, with emphasis on recent developments in the field, and discusses ongoing clinical trials.

引用

页码：629 / +

页数：19

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