Trace analysis by HPLC-MS:: contamination problems and systematic errors

被引：18
|
作者：
Oehme, M [1 ]
Berger, U [1 ]
Brombacher, S [1 ]
Kuhn, F [1 ]
Kölliker, S [1 ]
机构：
[1] Univ Basel, CH-4057 Basel, Switzerland
来源：
TRAC-TRENDS IN ANALYTICAL CHEMISTRY | 2002年 / 21卷 / 05期
关键词：
adsorption; artefacts; contamination; HPLC-MS; systematic errors; trace analysis;
D O I：
10.1016/S0165-9936(02)00503-4
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
HPLC-MS has been introduced into many laboratories during the past five years. However, this methodology is much more demanding than HPLC with optical detection or GC-MS. HPLC separations are still not optimised for MS and trace analysis. When working with trace quantities, there is considerable risk of problems caused by adsorption, contamination, surface reactions or other interferences. Transfer lines and ionisation processes can also cause systematic errors. This review summarises possible sources of error in HPLC-MS and suggests how to avoid them. Examples are given to illustrate problems. (C) 2002 Published by Elsevier Science B.V. All rights reserved.
引用
收藏
页码：322 / 331
页数：10
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