Synthesis of pyrimido[4,5-b]indoles and benzo[4,5]furo[2,3-d]pyrimidines via palladium-catalyzed intramolecular arylation

被引：42
|
作者：
Zhang, YM [1 ]
Razler, T [1 ]
Jackson, PF [1 ]
机构：
[1] Johnson & Johnson Pharmaceut Res & Dev, LLC, Raritan, NJ 08869 USA
来源：
TETRAHEDRON LETTERS | 2002年 / 43卷 / 46期
关键词：
D O I：
10.1016/S0040-4039(02)02036-1
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Various pyrimido[4,5-b]indoles and benzo[4,5]furo[2,3-d]pyrimidines were synthesized via a palladium-catalyzed intramolecular arylation of pyrimidine substrates. Thus, 4-aryloxy- or 4-anilino-5-iodopyrimidines were treated with Pd(OAc)(2)(PPh3)(2) and base in DMF to give the regioselective cyclized heterocycles. (C) 2002 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：8235 / 8239
页数：5
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