Factors Associated With CD8+ T-Cell Activation in HIV-1-Infected Patients on Long-term Antiretroviral Therapy

被引:29
|
作者
Zheng, Lu [1 ]
Taiwo, Babafemi [2 ]
Gandhi, Rajesh T. [3 ,4 ,5 ]
Hunt, Peter W. [6 ]
Collier, Ann C. [7 ]
Flexner, Charles [8 ]
Bosch, Ronald J. [1 ]
机构
[1] Harvard Univ, Sch Publ Hlth, Ctr Biostat AIDS Res, Boston, MA 02115 USA
[2] Northwestern Univ, Div Infect Dis, Chicago, IL 60611 USA
[3] Massachusetts Gen Hosp, Div Infect Dis, Boston, MA 02114 USA
[4] MIT, Ragon Inst MGH, Cambridge, MA 02139 USA
[5] Harvard, Cambridge, MA USA
[6] Univ Calif San Francisco, San Francisco Gen Hosp, Div HIV AIDS, San Francisco, CA USA
[7] Univ Washington, Dept Med, Div Infect Dis, Seattle, WA USA
[8] Johns Hopkins Univ, Sch Med, Div Clin Pharmacol, Baltimore, MD USA
基金
美国国家卫生研究院;
关键词
CD8(+) T-cell activation; viral suppression; age; HCV; CD4(+) T-cell count; HEPATITIS-C VIRUS; LOW-LEVEL VIREMIA; IMMUNE ACTIVATION; HIV-INFECTION; VIRAL SUPPRESSION; RNA LEVELS; RECOVERY; REPLICATION; REGIMENS; DISEASE;
D O I
10.1097/QAI.0000000000000286
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Background: Abnormal levels of CD8(+) T-cell activation persist in HIV-1-infected patients on suppressive antiretroviral therapy (ART) and may be deleterious. Methods: CD8+ T-cell activation (% coexpressing CD38/HLA-DR) was analyzed on blood specimens from 833 HIV-1-infected patients on ART for >= 96 weeks with concurrent plasma HIV RNA (vRNA) <= 200 copies per milliliter. Factors associated with CD8(+) T-cell activation were assessed using generalized estimating equations to incorporate longitudinal measurements (median 4/participant). Results: Participants were 84% men, 47% white, 28% black, and 22% Hispanic, with median pre-ART age 38 years and median ART exposure 144 weeks. CD8(+) T-cell activation was higher at time-points when vRNA was 51-200 versus <= 50 copies per milliliter [mean CD8(+) T-cell activation 23.4% vs. 19.7%; adjusted difference: 1.7% (95% confidence interval: 0.1 to 3.4), P = 0.042]. Restricting to vRNA <= 50 copies per milliliter, multivariable models showed the following factors associated with higher CD8(+) T-cell activation: older age [>= 45 vs. <= 30 years: 3.6% (1.4 to 5.7), P = 0.004], hepatitis C virus antibody positivity [3.6% (0.9 to 6.2), P = 0.032], Hispanic vs. white [7.2% (5.3 to 9.0), P < 0.001], lower concurrent CD4 count [<= 200 vs. >500 cells/mm(3): 2.2% (0.7 to 3.7), P < 0.001], lower concurrent CD4/CD8 ratio [-2.6% (-3.7 to -1.5) per 0.5 unit increase, P < 0.001], and higher pre-ART CD8+ T-cell activation [2.0% (1.6 to 2.5) per 10% higher, P < 0.001]. Conclusions: In participants included in our analysis, residual low-level viremia between 51 and 200 copies per milliliter during ART was shown to be associated with greater CD8(+) T-cell activation than full suppression to <50 copies per milliliter. Older age, hepatitis C virus antibody positivity, race/ethnicity, higher pre-ART CD8(+) T-cell activation, and lower concurrent CD4/CD8 ratio and CD4(+) T-cell count also contribute to greater CD8(+) T-cell activation during suppressive ART.
引用
收藏
页码:153 / 160
页数:8
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