Tailor-Made Semiconducting Polymers for Second Near-Infrared Photothermal Therapy of Orthotopic Liver Cancer

Liver tumor is one of the most lethal cancers due to its low ratio of surgical resection, high recurrence rate, and invasiveness. Photothermal therapy (PTT) possesses many advantages for cancer therapy because of its noninvasive nature. However, most PTT is conducted in the first near-infrared (NIR-I) window, so second near infrared (NIR-II) photosensitizers with higher penetrating ability and clinical prospects are seriously desirable. Herein, a semiconducting polymer with optimized absorption in NIR-I and NIR-II regions is obtained by ternary copolymerization methodology. The prepared nanoparticle (NP) from the semiconducting polymer is used for treatment of orthotopic liver cancer upon laser irradiation. Compared with an 808 nm laser, a 1064 nm laser leads to more effective inhibition toward orthotopic liver cancer in the same conditions. These results thus demonstrate that the NIR-II polymeric NPs may inspire another aspect for highly efficient therapy of various orthotopic cancers.