Telomere shortening with aging in the human pancreas

被引：53

作者：

Ishii, Akio

Nakamura, Ken-Ichi

Kishimoto, Hiroshi

Honma, Naoko

Aida, Junko

Sawabe, Motoji

Arai, Tomio

Fujiwara, Mutsunori

Takeuchi, Fujio

Kato, Motonobu

Oshimura, Mitsuo

Izumiyama, Naotaka

Takubo, Kaiyo

机构：

[1] Tokyo Metropolitan Inst Gerontol, Human Tissue Res Grp, Itabashi Ku, Tokyo 1730015, Japan

[2] Saitama Childrens Med Ctr, Dept Pathol, Iwatsuki, Saitama 3398551, Japan

[3] Tokyo Metropolitan Geriatr Med Ctr, Dept Pathol, Tokyo 1730015, Japan

[4] Japanese Red Cross Med Ctr, Dept Pathol, Tokyo 1508935, Japan

[5] Univ Tokyo, Fac Med, Dept Internal Med, Tokyo 1130033, Japan

[6] Tottori Univ, Sch Life Sci, Sch Med, Dept Biomed Sci, Yonago, Tottori 6830826, Japan

来源：

EXPERIMENTAL GERONTOLOGY | 2006年 / 41卷 / 09期

关键词：

pancreas; telomere; human aging; centenarian;

D O I：

10.1016/j.exger.2006.06.036

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

We have conducted systematic studies to measure telomere length in human tissues of all types. Progressive telomere shortening with aging was studied in specimens of normal pancreas obtained at autopsy from 69 subjects aged 0 to 100 yr, and age-related shortening of telomere length at a rate of 36 base pairs (bp) per year was detected. Mean telomere length (+/- SD) was 13.9 +/- 1.4 kilobase pairs (kbp) in 16 neonates, as opposed to 8.4 kbp in 2 centenarians. Mean telomere length (+/- SD) in four age groups, 0-24, 25-49, 50-74, and 75-100 yr, was 13.5 +/- 1.5, 12.3 +/- 0.7, 11.3 +/- 2.5, and 10.7 +/- 1.8, respectively. (c) 2006 Elsevier Inc. All rights reserved.

引用

页码：882 / 886

页数：5

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