Hydroxyethyl Starch-induced Pruritus: Clinical Characteristics and Influence of Dose, Molecular Weight and Substitution

被引:16
|
作者
Staender, Sonja [1 ]
Richter, Laura [1 ]
Osada, Nani [2 ]
Metze, Dieter [1 ]
机构
[1] Univ Hosp Munster, Dept Dermatol, Competence Ctr Chron Pruritus, DE-48149 Munster, Germany
[2] Univ Hosp Munster, Inst Informat, DE-48149 Munster, Germany
关键词
VISUAL ANALOG SCALE; PERSISTENT PRURITUS; FLUID RESUSCITATION; INFUSION THERAPY; SEVERE SEPSIS; LONG-TERM; HES; STORAGE; REPLACEMENT; MORTALITY;
D O I
10.2340/00015555-1639
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Severe persistent pruritus is a common, but incompletely characterized, complication of hydroxyethyl starch (HES) infusion. This retrospective study aimed to assess HES-induced pruritus by electron microscopic findings, pruritus characteristics, and response to stimuli, and to determine the impact of HES dosage, molecular weight and substitution. Seventy patients with electron microscopy-proven HES-induced pruritus were included. HES-laden vacuoles were observed in skin macrophages of all patients. The median latency between HES exposure and pruritus onset was 3 weeks, and the median duration of pruritus was 6 months. Pruritus was severe, or very severe, in 80% of patients. Mechanical stimuli triggered pruritus in 74% of patients. Although the median cumulative dose of HES was 300 g, 15% of patients developed pruritus after only 30 g. There were no significant differences between HES 130/0.4 and HES 200/0.5 in pruritus latency, duration or severity. HES-induced pruritus thus may occur at any dose, molecular weight or substitution. Key words: hydroxyethyl starch; tissue storage; pruritus; dose; molecular weight; molar substitution.
引用
收藏
页码:282 / 287
页数:6
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