White Matter Alterations in Depressive Disorder

被引：17
|
作者：
He, Enling [1 ]
Liu, Min [1 ]
Gong, Sizhu [1 ]
Fu, Xiyao [1 ]
Han, Yue [1 ]
Deng, Fang [1 ]
机构：
[1] Jilin Univ, Dept Neurol, Bethune Hosp 1, Changchun, Peoples R China
来源：
FRONTIERS IN IMMUNOLOGY | 2022年 / 13卷
基金：
中国国家自然科学基金;
关键词：
major depressive disorder; pathogenesis; white matter alterations; clinical relevance; depression; diffusion tenor imaging; TRANSCRANIAL MAGNETIC STIMULATION; MAJOR PSYCHIATRIC-DISORDERS; LATE-LIFE DEPRESSION; DYNAMIC CEREBRAL AUTOREGULATION; TREATMENT-RESISTANT DEPRESSION; COGNITIVE DYSFUNCTION; VASCULAR DEPRESSION; BLOOD-FLOW; HYPERINTENSITIES; ABNORMALITIES;
D O I：
10.3389/fimmu.2022.826812
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Depressive disorder is the most prevalent affective disorder today. Depressive disorder has been linked to changes in the white matter. White matter changes in depressive disorder could be a result of impaired cerebral blood flow (CBF) and CBF self-regulation, impaired blood-brain barrier function, inflammatory factors, genes and environmental factors. Additionally, white matter changes in patients with depression are associated with clinical variables such as differential diagnosis, severity, treatment effect, and efficacy assessment. This review discusses the characteristics, possible mechanisms, clinical relevance, and potential treatment of white matter alterations caused by depressive disorders.
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页数：10
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