Manganese-Catalyzed Ring-Opening Coupling Reactions of Cyclopropanols with Enones

被引：40

作者：

Zhang, Yong-Hui ^{[1
,2
,3
]}

Zhang, Wen-Wei ^{[3
]}

Zhang, Ze-Yu ^{[1
]}

Zhao, Kai ^{[1
]}

Loh, Teck-Peng ^{[1
,2
]}

机构：

[1] Nanjing Tech Univ, Jiangsu Natl Synerget Innovat Ctr Adv Mat, Sch Chem & Mol Engn, Inst Adv Synth, Nanjing 211816, Jiangsu, Peoples R China

[2] Nanyang Technol Univ, Sch Phys & Math Sci, Div Chem & Biol Chem, Singapore 637371, Singapore

[3] BGI Shenzhen, Shenzhen 518083, Peoples R China

来源：

ORGANIC LETTERS | 2019年 / 21卷 / 13期

基金：

中国国家自然科学基金;

关键词：

C-H ACTIVATION; BETA-CARBONYL RADICALS; BOND-CLEAVAGE; REGIOSPECIFIC SYNTHESIS; 7-MEMBERED CARBOCYCLES; OXIDATIVE CLEAVAGE; STRATEGY; DERIVATIVES; KETONES; ALKYL;

D O I：

10.1021/acs.orglett.9b01703

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A manganese-catalyzed ring-opening coupling reaction of cyclopropanols with enones for the facile and efficient preparation of 1,6-diketones is described. A wide array of synthetically important 1,6-diketones bearing manifold functional groups are obtained with up to 93% yield. These reactions feature broad substrate scopes, environmentally benign conditions, inexpensive catalyst, and operational simplicity.

引用

页码：5101 / 5105

页数：5

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