Increased cerebrospinal fluid levels of substance P in patients with amyotrophic lateral sclerosis

被引：18

作者：

Matsuishi, T

Nagamitsu, S

Shoji, H

Itoh, M

Takashima, S

Iwaki, T

Shida, N

Yamashita, Y

Sakai, T

Kato, H

机构：

[1] Kurume Univ, Sch Med, Dept Pediat & Child Hlth, Kurume, Fukuoka 8300011, Japan

[2] Kurume Univ, Sch Med, Dept Neurol Internal Med 1, Kurume, Fukuoka 830, Japan

[3] NCNP, Natl Inst Neurosci, Dept Mental Retardat & Birth Defect Res, Tokyo, Japan

[4] Kyushu Univ, Fac Med, Neurol Inst, Dept Neuropathol, Fukuoka 812, Japan

[5] Natl Chikugo Hosp, Dept Neurol, Fukuoka, Japan

来源：

JOURNAL OF NEURAL TRANSMISSION | 1999年 / 106卷 / 9-10期

关键词：

substance P; cerebrospinal fluid; amyotrophic lateral sclerosis;

D O I：

10.1007/s007020050214

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

To clarify the mechanism of brain and spinal cord impairment in amyotrophic lateral sclerosis (AES), we measured the cerebrospinal fluid (CSF) levels of substance P (SP) in 11 patients with sporadic ALS. Findings were compared with those obtained in controls and diseased controls. The CSF SP levels of patients with ALS, and particularly in patients with a disease duration of less than 2.5 years, were significantly higher than those in controls. These findings strongly suggested that SP may play an important role in the pathophysiology of ALS.

引用

页码：943 / 948

页数：6

共 50 条

[21] Investigation of levels of the vascular endothelial growth in cerebrospinal fluid in patients with amyotrophic lateral sclerosis
Vorobyeva, A.
Verhovskaya, L.
Shmarov, M.
Naroditsky, B.
Zakharova, M.
EUROPEAN JOURNAL OF NEUROLOGY, 2009, 16 : 653 - 653
[22] Neurofilament Subunit L Levels in the Cerebrospinal Fluid and Serum of Patients with Amyotrophic Lateral Sclerosis
Gong, Zhong-Ying
Lv, Gao-Peng
Gao, Li-Na
Lu, Yi
Guo, Jie
Zang, Da-Wei
NEURODEGENERATIVE DISEASES, 2018, 18 (2-3) : 165 - 172
[23] Cerebrospinal fluid levels of alpha-tocopherol in amyotrophic lateral sclerosis
F. de Bustos
F. J. Jiménez-Jiménez
J. A. Molina
J. Esteban
A. Guerrero-Sola
M. Zurdo
M. Ortí-Pareja
A. Tallón-Barranco
C. Gómez-Escalonilla
C. Ramírez-Ramos
J. Arenas
R. Enríquez de Salamanca
Journal of Neural Transmission, 1998, 105 : 703 - 708
[24] BIOMARKERS OF NEURODEGENERATION IN CEREBROSPINAL FLUID OF PATIENTS WITH AMYOTROPHIC LATERAL SCLEROSIS
Gulyaeva, N., V
Brylev, L., V
Yakovlev, A. A.
Nelkina, E. N.
Zakharova, M. N.
JOURNAL OF NEUROCHEMISTRY, 2011, 118 : 212 - 213
[25] Cerebrospinal fluid levels of alpha-tocopherol in amyotrophic lateral sclerosis
de Bustos, F
Jiménez-Jiménez, FJ
Molina, JA
Esteban, J
Guerrero-Sola, A
Zurdo, M
Ortí-Pareja, M
Tallón-Barranco, A
Gómez-Escalonilla, C
Ramírez-Ramos, C
Arenas, J
de Salamanca, RE
JOURNAL OF NEURAL TRANSMISSION, 1998, 105 (6-7) : 703 - 708
[26] CEREBROSPINAL FLUID ANGIOGENIN LEVEL IN PATIENTS WITH AMYOTROPHIC LATERAL SCLEROSIS
Ilzecka, Joanna
ACTA CLINICA CROATICA, 2008, 47 (02) : 77 - 79
[27] Cerebrospinal fluid filtration in amyotrophic lateral sclerosis
Finsterer, J
Mamoli, B
EUROPEAN JOURNAL OF NEUROLOGY, 1999, 6 (05) : 597 - 600
[28] Cerebrospinal fluid cytotoxicity in lateral amyotrophic sclerosis
Matias-Guiu, J.
Galan, L.
Garcia-Ramos, R.
Barcia, J. A.
Guerrero, A.
NEUROLOGIA, 2010, 25 (06): : 364 - 373
[29] Adiponectin levels in the serum and cerebrospinal fluid of amyotrophic lateral sclerosis patients: possible influence on neuroinflammation?
Patrizia Bossolasco
Raffaella Cancello
Alberto Doretti
Claudia Morelli
Vincenzo Silani
Lidia Cova
Journal of Neuroinflammation, 14
[30] Adiponectin levels in the serum and cerebrospinal fluid of amyotrophic lateral sclerosis patients: possible influence on neuroinflammation?
Bossolasco, Patrizia
Cancello, Raffaella
Doretti, Alberto
Morelli, Claudia
Silani, Vincenzo
Cova, Lidia
JOURNAL OF NEUROINFLAMMATION, 2017, 14

← 1 2 3 4 5 →