Increased cerebrospinal fluid levels of substance P in patients with amyotrophic lateral sclerosis

被引：18

作者：

Matsuishi, T

Nagamitsu, S

Shoji, H

Itoh, M

Takashima, S

Iwaki, T

Shida, N

Yamashita, Y

Sakai, T

Kato, H

机构：

[1] Kurume Univ, Sch Med, Dept Pediat & Child Hlth, Kurume, Fukuoka 8300011, Japan

[2] Kurume Univ, Sch Med, Dept Neurol Internal Med 1, Kurume, Fukuoka 830, Japan

[3] NCNP, Natl Inst Neurosci, Dept Mental Retardat & Birth Defect Res, Tokyo, Japan

[4] Kyushu Univ, Fac Med, Neurol Inst, Dept Neuropathol, Fukuoka 812, Japan

[5] Natl Chikugo Hosp, Dept Neurol, Fukuoka, Japan

来源：

JOURNAL OF NEURAL TRANSMISSION | 1999年 / 106卷 / 9-10期

关键词：

substance P; cerebrospinal fluid; amyotrophic lateral sclerosis;

D O I：

10.1007/s007020050214

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

To clarify the mechanism of brain and spinal cord impairment in amyotrophic lateral sclerosis (AES), we measured the cerebrospinal fluid (CSF) levels of substance P (SP) in 11 patients with sporadic ALS. Findings were compared with those obtained in controls and diseased controls. The CSF SP levels of patients with ALS, and particularly in patients with a disease duration of less than 2.5 years, were significantly higher than those in controls. These findings strongly suggested that SP may play an important role in the pathophysiology of ALS.

引用

页码：943 / 948

页数：6

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