Mapping New Residents of the Mitochondrial Nucleoid

被引：0
|
作者：
Trinkle-Mulcahy, Laura [1 ,2 ]
机构：
[1] Univ Ottawa, Ottawa Inst Syst Biol, Ottawa, ON K1H 8M5, Canada
[2] Univ Ottawa, Dept Cellular & Mol Med, Ottawa, ON K1H 8M5, Canada
来源：
CELL CHEMICAL BIOLOGY | 2017年 / 24卷 / 03期
关键词：
ENGINEERED ASCORBATE PEROXIDASE; PROTEINS; CELLS;
D O I：
10.1016/j.chembiol.2017.03.006
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
In this issue of Cell Chemical Biology, Han et al. (2017) used a powerful combination of quantitative ratiometric mass spectrometry with APEX peroxidase-catalyzed proximity biotinylation to selectively highlight proteins associated with mitochondrial DNA above the background of contaminants and matrix proteins. In addition to identifying novel nucleoid factors, this study extends the APEX strategy to the proteomic mapping of non-membrane-bound multiprotein complexes.
引用
收藏
页码：250 / 251
页数：2
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