Hyperbaric oxygen therapy: A physiological approach to selected problem wound healing

被引：0
|
作者：
Boykin, JV [1 ]
机构：
[1] METROPOLITAN HOSP, CTR HYPERBAR MED PROBLEM WOUND, RICHMOND, VA USA
来源：
WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE | 1996年 / 8卷 / 06期
关键词：
D O I：
暂无
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
Hyperbaric oxygen (HBO) therapy has been clinically demonstrated to significantly (p < 0.05) accelerate the healing of chronic wounds. HBO also inhibits activated neutrophil-endothelial adhesions which may lead to secondary oxygen free radical (OFR) production. Combined with recombinant platelet-derived growth factor (PDGF-BB) treatment, HBO significantly shortens ischemic ulcer healing as compared to either HBO or PDGF-BB treatment alone and upregulates PDGF-BB receptor mRNA activity. A review of the physiologic processes modified by HBO that may be responsible for accelerated and improved wound healing will be outlined. A clinical algorithm for transcutaneous oxygen monitoring (TCOM), patient evaluation, and HBO treatment will be discussed.
引用
收藏
页码：183 / 198
页数：16
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