2-Acetylbenzimidazole: a Valuable Synthon for the Synthesis of Biologically Active Molecules

被引：3
|
作者：
Padhy, Gopal Krishna [1 ,2 ]
Panda, Jagadeesh [3 ]
Raul, Saroj K. [4 ]
Behera, Ajaya K. [5 ]
机构：
[1] Centurion Univ Technol & Management, R Sitapur, Odisha, India
[2] Heritage Vis Educ Trust, Bhubaneswar, Odisha, India
[3] Raghu Coll Pharm, Visakhapatnam 531162, Andhra Pradesh, India
[4] Maharajahs Coll Pharm, Phool Baugh 535002, Vizianagaram, India
[5] Sambalpur Univ, Sch Chem, Organ Synth Lab, Jyoti Vihar 768019, Burla, India
来源：
BIOINTERFACE RESEARCH IN APPLIED CHEMISTRY | 2021年 / 11卷 / 04期
关键词：
2-Acetylbenzimidazole; chalcone; pyrazoline; pharmacology; synthesis; BENZIMIDAZOLE-DERIVED CHALCONES; ANTIMICROBIAL ACTIVITY; DERIVATIVES; ANTICANCER; DESIGN; ANTIBACTERIAL;
D O I：
10.33263/BRIAC114.1156211591
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
Benzimidazole is an important moiety from a medicinal chemistry perspective due to its various biological activities such as antimicrobial, anti-cancer, anti-diabetic, anti-Alzheimers, and anti-inflammatory, etc. 2-acetylbenzimidazole is exploited to obtain various heterocyclic compounds of pharmacological interest. This review's main motive is to present the literature on 2-acetylbenzimidazole chemistry and provide valuable and up-to-date information for its applications. The present review is carried out by compiling literature from 1964 to 2020 concerning the synthesis and biological aspects of various heterocyclic compounds derived from 2-acetylbenzimidazole. Literature was collected from various online search engines viz. Google Scholar, PubMed, Science Direct, Core, and Semantic scholar. 2-acetylbenzimidazole has been successfully employed as a synthon to obtain heterocyclic system viz. oxirane, pyrazoline, thiazole, pyrazole, isoxazoline, isoxazole, pyridine, pyrimidine, thiazine, diazepine, and other miscellaneous rings. 2-acetylbenzimidazole has shown promise for the convenient synthesis of various heterocyclic compounds. The reactions can be carried out on various reactive sites of 2-acetylbenzimidazole, which are the carbonyl group and the amino group. This review will help to explore various heterocyclic compounds and particularly in the synthesis of biologically useful compounds.
引用
收藏
页码：11562 / 11591
页数：30
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