Acutissimanide, a new lignan with antioxidant activity isolated from the bark of Quercus acutissima Carruth

被引：16

作者：

Zeng, Xiao-Li ^{[1
,2
]}

Fu, Guang-Miao ^{[1
,2
]}

Tian, Kai ^{[1
,2
]}

Sun, Jing-Xian ^{[1
,2
]}

Xiong, Hua-Bin ^{[1
,2
]}

Huang, Xiang-Zhong ^{[1
,2
,3
,4
,5
]}

Jiang, Zhi-Yong ^{[1
,2
]}

机构：

[1] Yunnan Univ Nationalities, Key Lab Chem Ethn Med Resources, State Ethn Affairs Commiss, Kunming 650500, Yunnan, Peoples R China

[2] Yunnan Univ Nationalities, Minist Educ, Sch Chem & Biotechnol, Kunming 650500, Yunnan, Peoples R China

[3] Chinese Acad Med Sci, Key Lab Bioact Subst & Resources Utilizat Chinese, Minist Educ, Beijing 100050, Peoples R China

[4] Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China

[5] Peking Union Med Coll, Beijing 100050, Peoples R China

来源：

NATURAL PRODUCT RESEARCH | 2014年 / 28卷 / 17期

基金：

中国国家自然科学基金;

关键词：

Q. acutissima Carruth; polyphenols; Acutissimanide; antioxidant activity;

D O I：

10.1080/14786419.2014.905557

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Acutissimanide (1), a new lignin, together with 11 known polyphenols (2-12) were isolated from the bark of the deciduous oak tree, Quercus acutissima Carruth. The structure of compound 1 was determined using multidimensional H-1 and C-13 NMR and mass spectroscopy. The antioxidant properties of compounds 1-12 were investigated using a 1,1-diphenyl-2-picryhydrazyl radical-scavenging assay with compounds 6-11 displaying significant antioxidant activity (EC50 values of 5.2-23.7 mu M). Our findings suggest the extracts of Q. acutissima Carruth are a potential source of natural antioxidant additives for use in the food and other allied industries.

引用

页码：1364 / 1370

页数：7

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