In Vitro Degradation of Poly (L-co-D, L lactic acid) Containing PCL-T

被引：7
|
作者：
Tomaz Duarte, Marcia Adriana [1 ]
de Rezende Duek, Eliana Aparecida p [2 ]
Motta, Adriana Cristina [3 ]
机构：
[1] SOCIESC, Tupy IST, Master Engn Mech, Florianopolis, SC, Brazil
[2] Univ Estadual Campinas, UNICAMP, Fac Mech Engn, Dept Mat Engn, Campinas, SP, Brazil
[3] PUC SP, Fac Med Sci, BR-18030095 Sorocaba, SP, Brazil
来源：
POLIMEROS-CIENCIA E TECNOLOGIA | 2014年 / 24卷 / 01期
关键词：
Bioresorbable polymer; in vitro degradation; PLDLA/PCL-T; IMPLANTS; FILMS; VIVO; BONE;
D O I：
10.4322/polimeros.2014.056
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
The application of polymer-based bioresorbable temporary devices in the medical field grows continuously, and professionals from several areas act to solve problems related to body functions lost due to diseases, accidents or natural wear. Here we study the influence from poly(caprolactonetriol) (PCL-T) on the degeneration process in the copolymer poly(L-co-DL-lactic acid) (PLDLA) membrane, by producing PLDLA/PCL-T blends with 90/10, 70/30 and 50/50 relative concentrations. The data for in vitro degradation showed that PCL-T decreases the rate of PLDLA. This was obtained with the following techniques: Differential Scanning Calorimetry (DSC), Thermogravimetric Analysis (TGA), Gel Permeation Chromatography (GPC) and Scanning Electron Microscopy (SEM). Therefore, it is possible to vary the membrane degradation rate by changing the blend composition, which is a tool to tailor a biomaterial.
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页码：1 / 8
页数：8
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