A novel strategy for the synthesis of medium-sized lactams

被引：56
|
作者：
Bieräugel, H
Jansen, TP
Schoemaker, HE
Hiemstra, H
van Maarseveen, JH
机构：
[1] Univ Amsterdam, Inst Mol Chem, NL-1018 WS Amsterdam, Netherlands
[2] DSM Res & Patents, Life Sci Prod, NL-6160 MD Geleen, Netherlands
来源：
ORGANIC LETTERS | 2002年 / 4卷 / 16期
关键词：
D O I：
10.1021/ol0261579
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
[GRAPHICS] A novel method for the synthesis of medium-sized lecterns based on an auxiliary-mediated combined tethered/templated strategy is presented. Cyclization by a tethered ring-closing metathesis reaction was followed by a templated transannular aminolysis reaction to give seven- to ten-membered lecterns in good yields.
引用
收藏
页码：2673 / 2674
页数：2
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