A comparison of the antihypertensive and metabolic effects of lisinopril 20 mg/hydrochlorothiazide 12.5 mg fixed combination with captopril 50 mg/hydrochlorothiazide 25 mg fixed combination

被引：0
|
作者：
Milon, H [1 ]
Baleydier, A [1 ]
机构：
[1] RCTS,F-69303 LYON 07,FRANCE
来源：
THERAPIE | 1997年 / 52卷 / 03期
关键词：
angiotensin converting enzyme inhibition; diuretic; antihypertensive treatment; lisinopril-hydrochlorothiazide combination; ambulatory blood pressure monitoring;
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The antihypertensive and metabolic effects of lisinopril 20 mg/hydrochlorothiazide 12.5 mg in fixed combination were compared with those of captopril 50 mg/hydrochlorothiazide 25 mg in fixed combination in a double-blind clinical trial. After a 3-week placebo run-in period, two parallel groups of hypertensive patients (185 patients in total) each received one treatment once a day for 6 weeks. Blood pressure was measured with a mercury sphygmomanometer and on two occasions by 24 h ambulatory blood pressure monitoring (ABPM). Results indicate that both treatments have similar effects on casual blood pressure measurements, while ABPM recordings show that the lisinopril 20 mg/hydrochlorothiazide 12.5 mg combination is more effective during the last period of the dosing interval. Lisinopril 20 mg/hydrochlorothiazide 12.5 mg as combination antihypertensive treatment does not induce alterations in serum potassium and triglycerides.
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页码：195 / 205
页数：11
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