Obesity-related cardiovascular disease: implications of obstructive sleep apnea

被引：55
|
作者：
Wolk, R [1 ]
Somers, VK [1 ]
机构：
[1] Mayo Clin, Dept Med, Div Cardiovasc Dis, Rochester, MN USA
来源：
DIABETES OBESITY & METABOLISM | 2006年 / 8卷 / 03期
关键词：
cardiovascular disease; obesity; sleep apnea;
D O I：
10.1111/j.1463-1326.2005.00508.x
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Obesity and obstructive sleep apnea (OSA) often coexist. OSA has been linked to cardiovascular disease. Thus, OSA may contribute to the cardiovascular consequences of obesity. In this review, we explore clinical and pathophysiological interactions between obesity, cardiovascular disease and OSA. We discuss the mechanisms whereby OSA may contribute to hypertension, atherosclerosis, insulin resistance and atrial fibrillation associated with obesity, and emphasize the potential implications for understanding why only a subgroup of obese patients develop cardiovascular disease. Identification of the OSA-dependent and OSA-independent pathways in the cardiovascular pathophysiology of obesity may hold clinical and therapeutic promise.
引用
收藏
页码：250 / 260
页数：11
相关论文
共 50 条
  • [21] Cardiovascular Implications in the Treatment of Obstructive Sleep Apnea
    Olivier M. Vanderveken
    An Boudewyns
    Quan Ni
    Bhavani Kashyap
    Johan Verbraecken
    Wilfried De Backer
    Paul Van de Heyning
    Journal of Cardiovascular Translational Research, 2011, 4 : 53 - 60
  • [22] Hemostatic alterations in patients with obstructive sleep apnea and the implications for cardiovascular disease
    von Känel, R
    Dimsdale, JE
    CHEST, 2003, 124 (05) : 1956 - 1967
  • [23] New Zealand Obese Mice as a Translational Model of Obesity-related Obstructive Sleep Apnea Syndrome
    Baum, David Marcel
    Rodriguez, Blanca Morales
    Attali, Valerie
    Cauhape, Margaux
    Arnulf, Isabelle
    Cardot, Philippe
    Bodineau, Laurence
    Fiamma, Marie-Noelle
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2018, 198 (10) : 1336 - 1339
  • [24] Excessive day sleepiness in obese subjects is not driven by obstructive sleep apnea: Is this another obesity-related sleep disorder?
    Dixon, J.
    Anderson, M.
    Dixon, M.
    Schachter, L.
    O'Brien, P.
    OBESITY SURGERY, 2006, 16 (08) : 990 - 990
  • [25] The regulation of aldosterone secretion by leptin: implications in obesity-related cardiovascular disease
    Faulkner, Jessica L.
    Bruder-Nascimento, Thiago
    de Chantemele, Eric J. Belin
    CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION, 2018, 27 (02): : 63 - 69
  • [26] Implications and Interventions Related to Obstructive Sleep Apnea
    Veenstra, Amy
    Untalan, Emylene
    CRITICAL CARE NURSING CLINICS OF NORTH AMERICA, 2014, 26 (04) : 499 - +
  • [27] Role of obstructive sleep apnea in cardiovascular disease
    Monahan, Ken
    Redline, Susan
    CURRENT OPINION IN CARDIOLOGY, 2011, 26 (06) : 541 - 547
  • [28] Obstructive Sleep Apnea and the Risk for Cardiovascular Disease
    Puja Kohli
    Jay S. Balachandran
    Atul Malhotra
    Current Atherosclerosis Reports, 2011, 13 : 138 - 146
  • [29] Obstructive Sleep Apnea and Cardiovascular Disease in Women
    Najjar, Nimeh
    Staiano, Peter
    Louis, Mariam
    CARDIOVASCULAR INNOVATIONS AND APPLICATIONS, 2019, 3 (04) : 421 - 434
  • [30] Obstructive Sleep Apnea and the Risk for Cardiovascular Disease
    Kohli, Puja
    Balachandran, Jay S.
    Malhotra, Atul
    CURRENT ATHEROSCLEROSIS REPORTS, 2011, 13 (02) : 138 - 146
12345