Assessment of ocular discomfort caused by 5 shampoos using the Slug Mucosal Irritation test

被引：5
|
作者：
Petit, Jean-Yanique [1 ]
Dore, Vanessa [1 ]
Marignac, Genevieve [1 ]
Perrot, Sebastien [1 ]
机构：
[1] Univ Paris Est, Ecole Natl Vet Alfort, Inst Rech Clin Anim, 7 Ave Gen Gaulle, F-94704 Maisons Alfort, France
来源：
TOXICOLOGY IN VITRO | 2017年 / 40卷
关键词：
Slug Mucosal Irritation test; Ocular discomfort; Veterinary shampoos; RABBIT NASAL-MUCOSA; BENZALKONIUM CHLORIDE; TOXICITY; REMOVAL; POTENCY; SURFACE; TOOL;
D O I：
10.1016/j.tiv.2017.01.002
中图分类号：
R99 [毒物学（毒理学）];
学科分类号：
100405 ;
摘要：
Assessment of ocular discomfort caused by veterinary care products is less legitimately regulated than that caused by human care products. The Slug Mucosal Irritation (SMI) assay was adapted to evaluate canine hygiene shampoos to predict ocular discomfort Experiments were performed using four commercial canine shampoos, a baby care product, and two controls (ArtTear (R) and BAC1%). Groups of 3 slugs were tested with 5% dilution of the 7 test substances. The negative control (ArtTear) was the best tolerated. The baby care product Mixa bebe as well as Douxo Entretien Demelant and Phlox Shampooing Entretien were classified to cause mild ocular discomfort. Together with the positive control (BAC 1%), Shampooing Physiologique Virbac and Physiovet Shampooing were considered to cause severe ocular discomfort. Different intensities of ocular discomfort were measured for veterinary care products. The SMI model was considered as a reproducible and adaptable evaluation method for screening veterinary care products causing ocular discomfort. (C) 2017 Elsevier Ltd. All rights reserved.
引用
收藏
页码：243 / 247
页数：5
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