Association of Chlamydia pneumoniae infection with diabetic nephropathy

被引：5

作者：

Kanauchi, M ^{[1
]}

Kawano, T ^{[1
]}

Dohi, K ^{[1
]}

机构：

[1] Nara Med Univ, Dept Internal Med 1, Kashihara, Nara 840, Japan

来源：

DIABETES RESEARCH AND CLINICAL PRACTICE | 2000年 / 47卷 / 01期

关键词：

Chlamydia pneumoniae; diabetic nephropathy; renal biopsy;

D O I：

10.1016/S0168-8227(99)00108-4

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We evaluated the association of Chlamydia pneumoniae (CP) infection with progression of diabetic nephropathy. Type 2 diabetic patients (60) were divided into two groups, those with incipient nephropathy and those with advanced nephropathy, based on the severity of diffuse glomerular lesions using Gellman's criteria. Type 2 (34) diabetic patients without nephropathy (normoalbuminuria) and 59 nondiabetics served as control groups. Serum IgG-antibody against CP was measured using ELISA. CP antibody was detected in 45.8% of nondiabetic controls, in 47.1% of diabetic patients without nephropathy, in 52.6% of diabetic patients with incipient nephropathy, and 78% of diabetic patients with advanced nephropathy. There was 4.22-fold increase in the risk of advanced nephropathy associated with the presence of CP antibody. Our findings indicate an association between chronic CP infection and advanced diabetic nephropathy. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：45 / 48

页数：4

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