DNA interaction and photonicking properties of DNA-targeted acridine (2,2′-bipyridine)platinum(II) complexes

被引：16
|
作者：
Gude, L
Fernández, MJ
Grant, KB [1 ]
Lorente, A
机构：
[1] Univ Alcala De Henares, Dept Quim Organ, Madrid 28871, Spain
[2] Georgia State Univ, Ctr Biotechnol & Drug Design, Dept Chem, Atlanta, GA 30303 USA
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2002年 / 12卷 / 21期
基金：
美国国家科学基金会;
关键词：
D O I：
10.1016/S0960-894X(02)00657-1
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Synthesis of two (2,2-bipyridine)platinum(II) complexes tethered to one or two acridine chromophores is reported. These acridine complexes efficiently unwind and photocleave supercoiled plasmid DNA under physiological conditions of temperature and pH. (C) 2002 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：3135 / 3139
页数：5
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