Platelet influence on T- and B-cell responses

被引：39
|
作者：
Sowa, Jennifer M. [1 ]
Crist, Scott A. [1 ]
Ratliff, Timothy L. [1 ,2 ]
Elzey, Bennett D. [1 ,3 ]
机构：
[1] Purdue Univ, Dept Comparat Pathobiol, W Lafayette, IN 47907 USA
[2] Purdue Univ, Purdue Canc Ctr, W Lafayette, IN 47907 USA
[3] Indiana Univ, Dept Urol, Indianapolis, IN 46204 USA
来源：
ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS | 2009年 / 57卷 / 04期
关键词：
platelets; CD154; T cells; B cells; SYSTEMIC-LUPUS-ERYTHEMATOSUS; SOLUBLE CD40 LIGAND; DENDRITIC CELLS; MEDIATED MODULATION; ALLOGRAFT-REJECTION; ADAPTIVE IMMUNITY; MEMBRANE-VESICLES; GERMINAL-CENTERS; P-SELECTIN; EXPRESSION;
D O I：
10.1007/s00005-009-0032-y
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Understanding the adaptive immune response is an area of research critically important in medicine. Several positive regulators of B- and T-cell activation exist to eliminate pathogens, in which CD40 ligand (CD154) plays a fundamental role. It is well documented that CD154 expressed by CD4 T helper cells can be critical in the proper activation of dendritic cells for the productive stimulation of CD8 T cells and is required for proper T-dependent B-cell immunity. However, platelets are an abundant and systemic source of CD154. While classically known to be important for hemostasis and inflammation, several lines of evidence suggest that platelet-derived ligands can modulate the adaptive immune compartment.
引用
收藏
页码：235 / 241
页数：7
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