Antifungal meroterpenes and dioxolanone derivatives from plant-associated endophytic fungus Phyllosticta sp. WGHL2

被引：8
|
作者：
Yan, Wei [1 ,2 ]
Zhao, Shuangshuang [1 ,2 ]
Gu, Chenguang [1 ,2 ]
Tian, Kailin [1 ,2 ]
Wang, Zhiyang [1 ,2 ]
Liu, Fang [3 ]
Ye, Yonghao [1 ,2 ]
机构：
[1] Nanjing Agr Univ, Coll Plant Protect, State & Local Joint Engn Res Ctr Green Pesticide, Nanjing 210095, Peoples R China
[2] Minist Educ, Key Lab Integrated Management Crop Dis & Pests, Nanjing 210095, Peoples R China
[3] Nanjing Agr Univ, Coll Sci, Nanjing 210095, Peoples R China
来源：
FITOTERAPIA | 2021年 / 148卷
基金：
中国国家自然科学基金;
关键词：
Endophytes; Phyllosticta sp. WGHL2; Meroterpenes; Dioxolanone derivatives; Antifungal activity; POTENTIAL MYCOHERBICIDE; NATURAL-PRODUCTS; METABOLITES; CIRSII;
D O I：
10.1016/j.fitote.2020.104778
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Four new meroterpenes named as guignardones U-X (1-4) 5 along with eleven known meroterpenes (5-15) and three known dioxolanone derivatives (16-18), were obtained from the endophytic fungus Phyllosticta sp. WGHL2. The structural elucidation was conducted by HRESIMS, NMR, single crystal X-ray diffraction, along with ECD calculations and comparison. In antifungal tests, compound 16 possessed broad-spectrum antifungal activities against Rhizoctonia solani, Fusarium graminearum and Botrytis cinerea with inhibition ratio of 48.43%, 40.98%, and 49.53% at 50 mu g/mL, respectively. Moreover, compound 16 showed moderate protective effect against B. cinerea in vivo at 200 mu g/mL and exhibited effective inhibition on the spore germination of B. cinerea.
引用
收藏
页数：7
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