Growth-inhibitory effects of a Bulnesia sarmienti aqueous extract on A549 Cells in vitro and S 180 cells in vivo

被引：4

作者：

Mollah, Mohammad Lalmoddin ^{[1
]}

Kim, Jung-Ok ^{[2
]}

Lee, Gee-Dong ^{[4
]}

Park, Chang-Ho ^{[4
]}

Hong, Joo-Heon ^{[4
]}

Kim, Hak-Yoon ^{[3
]}

Kim, Kil-Soo ^{[1
]}

机构：

[1] Kyungpook Natl Univ, Coll Vet Med, Taegu 702701, South Korea

[2] Daegu Gyeongbuk Inst Oriental Med Ind, Gyongsan, Gyeongbuk, South Korea

[3] Keimyung Univ, Fac Environm Studies, Taegu, South Korea

[4] Daegu Bio Ind Ctr, Taegu, South Korea

来源：

IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY | 2009年 / 31卷 / 03期

关键词：

Bulnesia sarmienti; growth inhibition; A549; cells; cytotoxicity; apoptosis; CANCER; APOPTOSIS; P53; CYCLE;

D O I：

10.1080/08923970902810432

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The effects of Bulnesia sarmienti (BS) aqueous extract on the cell growth of A549 cell lines were investigated. BS has strong cytotoxic activity on the A549 cell lines (IC50; less than 100 mu g/mL) in MTT assay. HPLC confirmed that BS contains catechins as major compound. Cell cycle analysis by flow cytometry indicated that BS arrested the cell cycle in the sub-G(1) phase. BS induced DNA fragmentation, and increased the expression of the p53 protein in immunoblot analysis. These results indicated that the anticancer effect of BS was mediated via the process of apoptosis and growth-inhibition.

引用

页码：492 / 498

页数：7

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