KPC-producing Klebsiella pneumoniae gut decolonisation following ceftazidime/avibactam-based combination therapy: A retrospective observational study

被引：6

作者：

Bassetti, Matteo ^{[1
,2
]}

Carannante, Novella ^{[3
]}

Pallotto, Carlo ^{[3
,4
]}

Righi, Elda ^{[1
,2
]}

Di Caprio, Giovanni ^{[5
]}

Bernardo, Mariano ^{[6
]}

Sodano, Giuseppe ^{[6
]}

Mallardo, Enza ^{[6
]}

Francisci, Daniela ^{[4
]}

Sartor, Assunta ^{[1
,2
]}

Graziano, Elena ^{[1
,2
]}

Tascini, Carlo ^{[3
]}

机构：

[1] Univ Udine, Dept Med, Infect Dis Div, Piazzale Santa Maria Misericordia 15, Udine, Italy

[2] Santa Maria Misericordia Univ Hosp, Piazzale Santa Maria Misericordia 15, Udine, Italy

[3] AORN Colli, Cotugno Hosp, Div Infect Dis 1, Via G Quagliariello 51, I-80131 Naples, Italy

[4] Univ Perugia, Dept Med, Infect Dis Sect, Piazzale Gambuli 1, Perugia, Italy

[5] Univ Campania Luigi Vanvitelli, Dept Mental Hlth & Publ Med, Infect Dis Sect, Naples, Italy

[6] AORN Colli, Cotugno Hosp, Microbiol & Virol Unit, Via G Quagliariello 51, Naples, Italy

来源：

JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE | 2019年 / 17卷

关键词：

Carbapenemase-producing Klebsiella pneumoniae; KPC; Ceftazidime/avibactam; Ceftazidime; Gut decolonisation; ORAL GENTAMICIN; RESISTANT; DECONTAMINATION; INFECTIONS; COLONIZATION; ERADICATION;

D O I：

10.1016/j.jgar.2018.11.014

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Objectives: KPC-producing Klebsiella pneumoniae (KPC-Kp) gut colonisation is a major risk factor for developing systemic infection. Ceftazidime/avibactam (CAZ/AVI) may have a role as decolonisation therapy in special situations. Methods: This was a retrospective, observational, multicentre study. The KPC-Kp gut decolonisation rate of CAZ/AVI-based therapy (Group A) was compared with other antimicrobial regimens (Group B) in patients with KPC-Kp infection. Results: Among 12 patients in Group A, 11 (91.7%) achieved gut decolonisation. None of the 24 patients of Group B were decolonised. Conclusion: CAZ/AVI-based therapy could be useful in KPC-Kp gut decolonisation in high-risk patients. (C) 2018 International Society for Chemotherapy of Infection and Cancer. Published by Elsevier Ltd. All rights reserved.

引用

页码：109 / 111

页数：3

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