To determine the characteristics of cerebral glucose metabolism in Parkinson's disease patients with visual hallucinations, group comparison studies using [F-18]fluorodeoxyglucose positron emission tomography were performed. Nondemented Parkinson's disease patients in advanced stages were classified into two groups: (1) patients without visual hallucinations; (2) patients with visual hallucinations. Compared to patients without hallucinations. the relative regional cerebral glucose metabolic rate was greater in the frontal areas in patients with visual hallucinations, and the increase reached a significant level in the left superior frontal gyrus. Relative frontal hypermetabolism may be a feature of Parkinson's disease patients with visual hallucinations. (C) 2004 Movement Disorder Society.
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Newcastle Univ, Clin Aging Res Unit, Inst Hlth & Aging, Newcastle Upon Tyne NE4 5PL, Tyne & Wear, EnglandNewcastle Univ, Clin Aging Res Unit, Inst Hlth & Aging, Newcastle Upon Tyne NE4 5PL, Tyne & Wear, England
Archibald, Neil K.
Clarke, Mike P.
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Royal Victoria Infirm, Newcastle Upon Tyne NE1 4LP, Tyne & Wear, EnglandNewcastle Univ, Clin Aging Res Unit, Inst Hlth & Aging, Newcastle Upon Tyne NE4 5PL, Tyne & Wear, England
Clarke, Mike P.
Mosimann, Urs P.
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Univ Bern, Dept Psychiat, Bern, SwitzerlandNewcastle Univ, Clin Aging Res Unit, Inst Hlth & Aging, Newcastle Upon Tyne NE4 5PL, Tyne & Wear, England
Mosimann, Urs P.
Burn, David J.
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机构:Newcastle Univ, Clin Aging Res Unit, Inst Hlth & Aging, Newcastle Upon Tyne NE4 5PL, Tyne & Wear, England