Efficient synthesis of substituted 2-(4H-1,3-benzoxazin-2-yl) phenols via a pseudo three-component reaction

被引：1
|
作者：
Wang, Ting [1 ]
Dai, Chenlu [1 ]
Qing, Xushun [1 ]
Wang, Cunde [1 ]
机构：
[1] Yangzhou Univ, Sch Chem & Chem Engn, 180 Siwangting St, Yangzhou 225002, Jiangsu, Peoples R China
来源：
JOURNAL OF CHEMICAL RESEARCH | 2018年 / 03期
基金：
中国国家自然科学基金;
关键词：
4H-1,3-benzoxazine; pseudo three-component reaction; substituted; 2-hydroxybenzaldehyde; oxazine; annulation reaction; DNA-PK; INHIBITORS; PI3K; ALDEHYDES; DESIGN; POTENT;
D O I：
10.3184/174751918X15199181776822
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
An efficient pseudo three-component reaction between substituted 2-hydroxybenzaldehydes and ammonium acetate for the preparation of substituted 2-(4H-1,3-benzoxazin-2-yl) phenols in moderate to good yields (70-80%) was developed. The structure of a typical product was confirmed by X-ray crystallography.
引用
收藏
页码：121 / 124
页数：4
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