Biofunctionalization of PEO coatings on titanium implants with inorganic and organic substances

被引：36

作者：

Parfenov, Evgeny ^{[1
]}

Parfenova, Lyudmila ^{[2
]}

Mukaeva, Veta ^{[1
]}

Farrakhov, Ruzil ^{[1
]}

Stotskiy, Andrey ^{[1
]}

Raab, Arseniy ^{[1
]}

Danilko, Ksenia ^{[3
]}

Rameshbabu, Nagumothu ^{[4
]}

Valiev, Ruslan ^{[1
]}

机构：

[1] Ufa State Aviat Tech Univ, Ufa, Russia

[2] Russian Acad Sci, Inst Petrochem & Catalysis, Moscow, Russia

[3] Bashkir State Med Univ, Ufa, Russia

[4] Natl Inst Technol, Tiruchirappalli, Tamil Nadu, India

来源：

SURFACE & COATINGS TECHNOLOGY | 2020年 / 404卷

基金：

俄罗斯科学基金会;

关键词：

Titanium implants; Plasma electrolytic oxidation; Microarc oxidation; Biocompatible coatings; Hydroxyapatite; RGD-peptide; VITRO BIOLOGICAL RESPONSE; IN-VITRO; SURFACE CHARACTERIZATION; CORROSION BEHAVIOR; MAGNESIUM ALLOY; PHOSPHONIC ACID; PLASMA; HYDROXYAPATITE; TI; ANTIBACTERIAL;

D O I：

10.1016/j.surfcoat.2020.126486

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

The paper concerns a choice in the biofunctionalization of the coatings produced by plasma electrolytic oxidation: either with inorganic components by introducing Ca-, P- containing compounds into the coating (primarily hydroxyapatite), or with integrin-active organic components (primarily RGD peptides). The following coatings were analyzed: E1 - titania PEO coating, E2 - titania and Ca-, P containing PEO coating, E1- RGD titania PEO coating modified with integrin-active RGD (arginine-glycine-aspartic acid) tripeptide sequence anchored to the surface with a bisphosphonate linker. In terms of wear resistance, electrochemical corrosion behavior, and interaction with osteoblast-like cells, coating E1 + RGD seems to be the most promising for the titanium implants.

引用

页数：11

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