Biofunctionalization of PEO coatings on titanium implants with inorganic and organic substances

被引：36
|
作者：
Parfenov, Evgeny [1 ]
Parfenova, Lyudmila [2 ]
Mukaeva, Veta [1 ]
Farrakhov, Ruzil [1 ]
Stotskiy, Andrey [1 ]
Raab, Arseniy [1 ]
Danilko, Ksenia [3 ]
Rameshbabu, Nagumothu [4 ]
Valiev, Ruslan [1 ]
机构：
[1] Ufa State Aviat Tech Univ, Ufa, Russia
[2] Russian Acad Sci, Inst Petrochem & Catalysis, Moscow, Russia
[3] Bashkir State Med Univ, Ufa, Russia
[4] Natl Inst Technol, Tiruchirappalli, Tamil Nadu, India
来源：
SURFACE & COATINGS TECHNOLOGY | 2020年 / 404卷
基金：
俄罗斯科学基金会;
关键词：
Titanium implants; Plasma electrolytic oxidation; Microarc oxidation; Biocompatible coatings; Hydroxyapatite; RGD-peptide; VITRO BIOLOGICAL RESPONSE; IN-VITRO; SURFACE CHARACTERIZATION; CORROSION BEHAVIOR; MAGNESIUM ALLOY; PHOSPHONIC ACID; PLASMA; HYDROXYAPATITE; TI; ANTIBACTERIAL;
D O I：
10.1016/j.surfcoat.2020.126486
中图分类号：
TB3 [工程材料学];
学科分类号：
0805 ; 080502 ;
摘要：
The paper concerns a choice in the biofunctionalization of the coatings produced by plasma electrolytic oxidation: either with inorganic components by introducing Ca-, P- containing compounds into the coating (primarily hydroxyapatite), or with integrin-active organic components (primarily RGD peptides). The following coatings were analyzed: E1 - titania PEO coating, E2 - titania and Ca-, P containing PEO coating, E1- RGD titania PEO coating modified with integrin-active RGD (arginine-glycine-aspartic acid) tripeptide sequence anchored to the surface with a bisphosphonate linker. In terms of wear resistance, electrochemical corrosion behavior, and interaction with osteoblast-like cells, coating E1 + RGD seems to be the most promising for the titanium implants.
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页数：11
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